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Titolo:
High-performance liquid chromatographic study of the interactions between immobilized beta-cyclodextrin polymers and hydrophobically end-capped polyethylene glycols
Autore:
David, C; Millot, MC; Sebille, B;
Indirizzi:
CNRS, UMR C7581, Lab Rech Polymeres, F-94320 Thiais, France CNRS Thiais France F-94320 1, Lab Rech Polymeres, F-94320 Thiais, France
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 753, anno: 2001,
pagine: 93 - 99
SICI:
1387-2273(20010325)753:1<93:HLCSOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE AFFINITY-CHROMATOGRAPHY; INCLUSION-COMPOUNDS; STRUCTURAL ISOMERS; SEPARATION; ASSOCIATION; PHASES;
Keywords:
beta-cyclodextrin; polyethylene glycol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Millot, MC CNRS, UMR C7581, Lab Rech Polymeres, 2-8 Rue Henri Dunant, F-94320 Thiais,France CNRS 2-8 Rue Henri Dunant Thiais France F-94320 Thiais,France
Citazione:
C. David et al., "High-performance liquid chromatographic study of the interactions between immobilized beta-cyclodextrin polymers and hydrophobically end-capped polyethylene glycols", J CHROMAT B, 753(1), 2001, pp. 93-99

Abstract

The formation of inclusion complexes between polyethylene glycols (PEGs) bearing hydrophobic ends (naphtyl and phenyladamantyl) and beta -cyclodextrin polymers (poly beta -CD) immobilized onto silica particles was studied byhigh-performance liquid chromatography (HPLC). It was shown that hydrophobic interactions were involved in the retention mechanism of these compounds, since retention volumes decreased when organic solvents were added to themobile phase while it was the contrary in the presence of salts. Moreover,the association could be reversed by adding a competitor (hydroxypropyl beta -cyclodextrin) to the mobile phase. A theoretical model permitted the evaluation of affinity constants of 1:1 complexes formed between the modifiedPEGs and the immobilized poly beta -CD which depended on the type of hydrophobic groups grafted to the PEG. (C) 2001 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:51:26