Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differences in skeletal muscle between men and women with chronic heart failure
Autore:
Duscha, BD; Annex, BH; Keteyian, SJ; Green, HJ; Sullivan, MJ; Samsa, GP; Brawner, CA; Schachat, FH; Kraus, WE;
Indirizzi:
Duke Univ, Med Ctr, Dept Med, Div Cardiol,Duke Ctr Living, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 rdiol,Duke Ctr Living, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Cell Biol, Durham, NC 27710 USA Henry Ford Hosp, Henry Ford Heart & Vasc Inst, Detroit, MI 48202 USA HenryFord Hosp Detroit MI USA 48202 t & Vasc Inst, Detroit, MI 48202 USA Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada Univ Waterloo Waterloo ON Canada N2L 3G1 ol, Waterloo, ON N2L 3G1, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 280 - 286
SICI:
8750-7587(200101)90:1<280:DISMBM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-ACTIVITIES; EXERCISE; PERFORMANCE; SURVIVAL; DETERMINANTS; MORTALITY; GENDER;
Keywords:
oxygen consumption; exercise; capillary density;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Duscha, BD Duke Univ, Med Ctr, Dept Med, Div Cardiol,Duke Ctr Living, Box 3022, Durham, NC 27710 USA Duke Univ Box 3022 Durham NC USA 27710 22, Durham, NC 27710 USA
Citazione:
B.D. Duscha et al., "Differences in skeletal muscle between men and women with chronic heart failure", J APP PHYSL, 90(1), 2001, pp. 280-286

Abstract

Men with chronic heart failure (CHF) have alterations in their skeletal muscle that are partially responsible for a decreased exercise tolerance. Thepurpose of this study was to investigate whether skeletal muscle alterations in women with CHF are similar to those observed in men and if these alterations are related to exercise intolerance. Twenty-five men and thirteen women with CHF performed a maximal exercise test for evaluation of peak oxygen consumption ((V) over dotO(2)) and resting left ventricular ejection fraction, after which a biopsy of the vastus lateralis was performed. Twenty-one normal subjects (11 women, 10 men) were also studied. The relationship between muscle markers and peak (V) over dotO(2) was consistent for CHF men and women. When controlling for gender, analysis showed that oxidative enzymes and capillary density are the best predictors of peak (V) over dotO(2). These results indicate that aerobically matched CHF men and women have no differences in skeletal muscle biochemistry and histology. However, when CHF groups were separated by peak exercise capacity of 4.5 metabolic equivalents (METs), CHF men with peak (V) over dotO(2) >4.5 METs had increased citrate synthase and 8-hydroxyacyl-CoA dehydrogenase compared with CHF men withpeak (V) over dotO(2) <4.5 METs. CHF men with a lower peak ire, had increased capillary density compared with men with higher peak (V) over dotO(2). These observations were not reproduced in CHF women. This suggests that differences may exist in how skeletal muscle adapts to decreasing peak (V) over dotO(2) in patients with CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:46:55