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Titolo:
PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat
Autore:
Calvijo, LC; Carter, MB; Matheson, PJ; Wilson, MA; Wead, WB; Garrison, RN;
Indirizzi:
Univ Louisville, Ctr Excellence Appl Microcirculatory Res, Louisville, KY 40206 USA Univ Louisville Louisville KY USA 40206 ory Res, Louisville, KY 40206 USA Univ Louisville, Dept Physiol & Biophys, Louisville, KY 40206 USA Univ Louisville Louisville KY USA 40206 Biophys, Louisville, KY 40206 USA Univ Louisville, Dept Surg, Louisville, KY 40206 USA Univ Louisville Louisville KY USA 40206 pt Surg, Louisville, KY 40206 USA Vet Affairs Med Ctr, Louisville, KY 40206 USA Vet Affairs Med Ctr Louisville KY USA 40206 Ctr, Louisville, KY 40206 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 261 - 268
SICI:
8750-7587(200101)90:1<261:PIVPWI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; HUMAN-ENDOTHELIAL-CELLS; EVANS BLUE-DYE; INTESTINAL ISCHEMIA; LUNG INJURY; NEUTROPHILS; SEPSIS; ANTAGONISTS; EDEMA;
Keywords:
platelet-activating factor; septic shock; gram negative; lung injury; pulmonary edema; videomicroscopy; pulmonary arterial catheterization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Matheson, PJ Univ Louisville, Ctr Excellence Appl Microcirculatory Res, 800 Zorn Ave,Res Bldg 19, Louisville, KY 40206 USA Univ Louisville 800 Zorn Ave,Res Bldg 19 Louisville KY USA 40206
Citazione:
L.C. Calvijo et al., "PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat", J APP PHYSL, 90(1), 2001, pp. 261-268

Abstract

In vivo pulmonary arterial catheterization was used to determine the mechanism by which platelet-activating factor (PAF) produces pulmonary edema in rats. PAF induces pulmonary edema by increasing pulmonary microvascular permeability (PMP) without changing the pulmonary pressure gradient. Rats werecannulated for measurement of pulmonary arterial pressure (Ppa) arid mean arterial pressure. PMP was determined by using either in vivo fluorescent videomicroscopy or the ex vivo Evans blue dye technique. WEB 2086 was administered intravenously (TV) to antagonize specific PAF effects, Three experiments were performed: 1) IV PAF, 2) topical PAF, and 3) Escherichia coli bacteremia. IV PAF induced systemic hypotension with a decrease in Ppa. PMP increased after IV PAF in a dose-related manner. Topical PAF increased PMP but decreased Ppa only at high doses. Both PMP (88 +/- 5%) and Ppa (50 +/- 3%) increased during E. coli bacteremia. PAF-receptor blockade prevents changes in Ppa and PMP after both topical PAF and E. coli bacteremia. PAF, whichhas been shown to mediate pulmonary edema in prior studies, appears to actin the lung by primarily increasing microvascular permeability. The presence of PAF might be prerequisite for pulmonary vascular constriction during gram-negative bacteremia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:27:30