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Titolo:
Dorsomedial medulla is more susceptible than rostral ventrolateral medullato hypoxic insult in cats
Autore:
Hong, LZ; Kuo, JS; Yen, MH; Chai, CY;
Indirizzi:
Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 inica, Inst Biomed Sci, Taipei 115, Taiwan Natl Def Med Ctr, Grad Inst Life Sci, Taipei 100, Taiwan Natl Def Med CtrTaipei Taiwan 100 rad Inst Life Sci, Taipei 100, Taiwan Taichung Vet Gen Hosp, Dept Educ & Med Res, Taichung 40705, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 40705 Res, Taichung 40705, Taiwan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 248 - 260
SICI:
8750-7587(200101)90:1<248:DMIMST>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; SYMPATHOEXCITATORY NEURONS; PRESSOR-RESPONSES; VASOMOTOR NEURONS; BRAIN-STEM; IN-VITRO; DESENSITIZATION; OXYGEN; RATS; MECHANISMS;
Keywords:
vertebral sympathetic nerve; reoxygenation; decerebration; baroreceptor; chemoreceptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Chai, CY Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 st Biomed Sci, Taipei 115, Taiwan
Citazione:
L.Z. Hong et al., "Dorsomedial medulla is more susceptible than rostral ventrolateral medullato hypoxic insult in cats", J APP PHYSL, 90(1), 2001, pp. 248-260

Abstract

We investigated the responses of systemic arterial pressure and vertebral sympathetic nerve activity to glutamate microinjections (0.1 M, 70 nl) in the dorsomedial (DM) and the rostral ventrolateral medulla (RVLM) before hypoxia and after reoxygenation (posthypoxia) after various degrees of hypoxiain anesthetized cats. Hypoxia was produced by ventilating 5% O-2 and 95% N-2 for different durations (hypoxia I-III). In intact cats, the glutamate-induced systemic arterial pressure and vertebral nerve activity responses ofthe DM were depressed after all degrees of hypoxia. Posthypoxic depressionin the RVLM, however, was not observed until hypoxia II and III. Precollicular decerebration prevented depression in the RVLM, but, for the DM, it was effective only for hypoxia I. Baro- and chemoreceptor denervation abolished all posthypoxic depression in both the DM and the RVLM. Presser responses to tyramine (100-400 mug/kg iv) remained unchanged after all degrees of hypoxia. These results suggest that the DM is more susceptible to hypoxia than the RVLM. The peripheral baro- and chemoreceptors and the suprapontine structures apparently play an important role in posthypoxic depression. Moreover, the depression is not due to the postganglionic norepinephrine depletion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:36:08