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Titolo:
Interaction of gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries
Autore:
Laughlin, MH; Schrage, WG; McAllister, RM; Garverick, HA; Jones, AW;
Indirizzi:
Univ Missouri, Dept Vet Biomed Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 et Biomed Sci, Columbia, MO 65211 USA Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri, Dept Med Physiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 t Med Physiol, Columbia, MO 65211 USA Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 216 - 227
SICI:
8750-7587(200101)90:1<216:IOGAET>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATIONS; CORONARY RESISTANCE ARTERIES; SYNTHASE GENE-EXPRESSION; NITRIC-OXIDE; POSTMENOPAUSAL WOMEN; MEDIATED DILATION; HEART-DISEASE; ESTROGEN; RESPONSES; DOGS;
Keywords:
endothelium; acetylcholine; skeletal muscle blood flow; vascular smooth muscle; N-G-nitro-L-arginine methyl ester; endothelin-derived relaxing factor; indomethacin; nitric oxide; prostacyclin; endothelin; A-23187; nitroprusside;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Laughlin, MH Univ Missouri, Dept Vet Biomed Sci, E-102 Vet Med Bldg, Columbia, MO 65211USA Univ Missouri E-102 Vet Med Bldg Columbia MO USA 65211 211USA
Citazione:
M.H. Laughlin et al., "Interaction of gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries", J APP PHYSL, 90(1), 2001, pp. 216-227

Abstract

The purpose of the present study was to test the hypothesis that gender influences exercise training-induced adaptations of vascular reactivity of porcine arteries that provide blood flow to skeletal muscle and femoral and brachial arteries. Male and female Yucatan miniature swine were exercise trained on a motor-driven treadmill or cage confined for 16-20 wk. Contractileresponses of arterial rings were evaluated in vitro by determining concentration-response curves for endothelin-1 (ET-1; 10(-10) to 10(-7) M) and norepinephrine (NE; 10(-10) to 10(-4) M). Relaxation responses of arteries precontracted with 30 muM PGF(2 alpha) were examined for endothelium-dependentagents [bradykinin (BK; 10(-11) to 10(-6) M), ACh (10(-10) to 10(-4) M), and a Ca2+ ionophore, A-23187 (10(-6) M)] and a endothelium-independent agent [sodium nitroprusside (10(-10) to 10(-4) M)]. Arteries from female pigs developed greater contractile force in response to ET-1 than arteries from male pigs, whereas contractile responses to NE and KCl were similar in arteries from both genders. Femoral arteries from females exhibited greater endothelium-mediated vasorelaxation (BK and ACh) than did those from males. In contrast, brachial arteries of males were more responsive to BK and ACh than brachial arteries of females. Exercise training increased ET-1-induced contractions in arteries from males (without endothelium) but not in arteriesfrom females. Training had no effect on endothelium-dependent relaxation in arteries from males but increased relaxation responses in brachial arteries from females. We conclude that both gender and anatomic origin of the artery influence exercise training-induced adaptations of vascular reactivityof porcine skeletal muscle conduit arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:50:23