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Titolo:
Short-term 17 beta-estradiol decreases glucose R-a but not whole body metabolism during endurance exercise
Autore:
Carter, S; McKenzie, S; Mourtzakis, M; Mahoney, DJ; Tarnopolsky, MA;
Indirizzi:
McMaster Univ, Med Ctr, Dept Neurol, Hamilton, ON L8N 3Z5, Canada McMasterUniv Hamilton ON Canada L8N 3Z5 ol, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ed, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Rehabil, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 il, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Dept Kinesiol, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ol, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 139 - 146
SICI:
8750-7587(200101)90:1<139:S1BDGR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE ACTIVITY; TISSUE GLYCOGEN-METABOLISM; MALE-RATS; CARBOHYDRATE-METABOLISM; LIPID AVAILABILITY; GENDER DIFFERENCES; MENSTRUAL-CYCLE; MUSCLE GLYCOGEN; ESTRADIOL; WOMEN;
Keywords:
gender differences; glycogenolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tarnopolsky, MA McMaster Univ, Med Ctr, Dept Neurol, Rm 4U4,1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ Rm 4U4,1200 Main St W HamiltonON Canada L8N 3Z5
Citazione:
S. Carter et al., "Short-term 17 beta-estradiol decreases glucose R-a but not whole body metabolism during endurance exercise", J APP PHYSL, 90(1), 2001, pp. 139-146

Abstract

The female sex hormone 17 beta -estradiol (E-2) has been shown to increaselipid and decrease carbohydrate utilization in animals. We administrated oral E-2 and placebo (randomized, double blind, crossover) to eight human male subjects for 8 days (similar to3 mg/day) and measured respiratory variables, plasma substrates, hormones (E-2, testosterone, leptin, cortisol, insulin, and catecholamines), and substrate utilization during 90 min of endurance exercise. [6,6-H-2]glucose and [1,1,2,3,3-H-2]glycerol tracers were used to calculate substrate flux. E-2 administration increased serum E-2 (0.22to 2.44 nmol/l, P < 0.05) and decreased serum testosterone (19.4 to 11.5 nmol/l, P < 0.05) concentrations, yet there were no treatment effects on anyof the other hormones. Glucose rates of appearance (R-a) and disappearance(R-d) were lower, and glycerol R-a-to-R-d ratio was not affected by E-2 administration. O-2 uptake, CO2 production, and respiratory exchange ratio were not affected by E-2; however, there was a decrease in heart rate (P < 0.05). Plasma lactate and glycerol were unaffected by E-2; however, glucose was significantly higher (P < 0.05) during exercise after E-2 administration. We concluded that short-term oral E-2 administration decreased glucose R-a and R-d, maintained plasma glucose homeostasis, but had no effect on substrate oxidation during exercise in men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:57:36