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Titolo:
Energetic driving forces are maintained in resting rat skeletal muscle after dietary creatine supplementation
Autore:
McMillen, J; Donovan, CM; Messer, JI; Willis, WT;
Indirizzi:
Arizona State Univ, Exercise & Sport Res Inst, Tempe, AZ 85287 USA ArizonaState Univ Tempe AZ USA 85287 Sport Res Inst, Tempe, AZ 85287 USA Univ So Calif, Dept Exercise Sci, Los Angeles, CA 90089 USA Univ So CalifLos Angeles CA USA 90089 ise Sci, Los Angeles, CA 90089 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 62 - 66
SICI:
8750-7587(200101)90:1<62:EDFAMI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPEATED BOUTS; EXERCISE; PERFORMANCE; PHOSPHOCREATINE; KINASE; INTERMITTENT; METABOLISM; PHOSPHATE; FIBERS; MODEL;
Keywords:
energy phosphates; thermodynamics; ergogenic aids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Willis, WT Arizona State Univ, Exercise & Sport Res Inst, Tempe, AZ 85287 USA Arizona State Univ Tempe AZ USA 85287 nst, Tempe, AZ 85287 USA
Citazione:
J. McMillen et al., "Energetic driving forces are maintained in resting rat skeletal muscle after dietary creatine supplementation", J APP PHYSL, 90(1), 2001, pp. 62-66

Abstract

The total creatine (TCr) pool of skeletal muscle is composed of creatine (Cr) and phosphocreatine (PCr). In resting skeletal muscle, the ratio of PCrto TCr (PCr/TCr; PCr energy charge) is similar to0.6-0.8, depending on thefiber type. PCr/TCr is linked to the cellular free energy of ATP hydrolysis by the Cr kinase equilibrium. Dietary Cr supplementation increases TCr inskeletal muscle. However, many previous studies have reported data indicating that PCr/TCr falls after supplementation, which would suggest that Cr supplementation alters the resting energetic state of myocytes. This study investigated the effect of Cr supplementation on the energy phosphates of resting skeletal muscle. Male rats were fed either rodent chow (control) or chow supplemented with 2% (wt/wt) Cr. After 2 wk on the diet, the gastrocnemius and soleus muscles were freeze clamped and removed from anesthetized animals. Cr supplementation increased TCr, PCr, and Cr levels in the gastrocnemius by 20, 22, and 17%, respectively (P < 0.05). A numerical 6% higher mean soleus TCr in Cr-supplemented rats was not statistically significant. All other energy phosphate concentrations, free energy of ATP hydrolysis, andPCr/TCr were not different between the two groups in either muscle. We conclude that Cr supplementation simply increased TCr in fast-twitch rat skeletal muscle but did not otherwise alter resting cellular energetic state.

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Documento generato il 12/07/20 alle ore 02:18:51