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Titolo:
Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs
Autore:
Sakuma, T; Tuchihara, C; Ishigaki, M; Osanai, K; Nambu, Y; Toga, H; Takahashi, K; Ohya, N; Kurihara, T; Matthay, MA;
Indirizzi:
Kanazawa Med Univ, Dept Pulm Med, Uchinade, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinade Ishikawa Japan 9200293 Ishikawa 9200293, Japan Kanazawa Med Univ, Dept Basic Med Sci, Uchinade, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinade Ishikawa Japan 9200293 Ishikawa 9200293, Japan Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Cardiovasc Res Inst, Dept Anesthesia, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 90, anno: 2001,
pagine: 10 - 16
SICI:
8750-7587(200101)90:1<10:DABAIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID CLEARANCE; II CELLS; PROTEIN CLEARANCE; SODIUM-CHANNELS; IN-SITU; TRANSPORT; ABSORPTION; SHEEP; TERBUTALINE; STIMULATION;
Keywords:
pulmonary edema; sodium transport; alveolar epithelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sakuma, T Kanazawa Med Univ, Dept Pulm Med, Uchinade, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinade Ishikawa Japan 9200293 200293, Japan
Citazione:
T. Sakuma et al., "Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs", J APP PHYSL, 90(1), 2001, pp. 10-16

Abstract

The effect of denopamine, a selective beta (1)-adrenergic agonist, on alveolar fluid clearance was determined in both ex vivo rat and guinea pig lungs. Alveolar fluid clearance was measured by the progressive increase in theconcentration of Evans blue-labeled albumin over 1 h at 37 degreesC. Denopamine (10(-6) to 10(-3) M) increased alveolar fluid clearance in a dose-dependent manner in ex vivo rat lungs. Denopamine also stimulated alveolar fluid clearance in guinea pig lungs. Atenolol, a selective beta (1)-adrenergicantagonist, and amiloride, a sodium channel inhibitor, inhibited denopamine-stimulated alveolar fluid clearance. The potency of denopamine was similar to that of similar doses of isoproterenol or terbutaline. Shortterm hypoxia (100% nitrogen for 1-2 h) did not alter the stimulatory effect of denopamine. Denopamine (10(-4), 10(-3) M) increased intracellular adenosine 3',5'-cyclic monophosphate levels in cultured rat alveolar type II cells. In summary, denopamine, a selective beta (1)-adrenergic agonist, stimulates alveolar fluid clearance in both ex vivo rat and guinea pig lungs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:32:19