Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs
Autore:
Bergren, DR;
Indirizzi:
Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 d, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 695 - 704
SICI:
8750-7587(200102)90:2<695:CTSEIA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKE; BAROMETRIC PLETHYSMOGRAPHY; NONINVASIVE MEASUREMENT; PASSIVE SMOKING; C-FIBERS; HYPERRESPONSIVENESS; INFLAMMATION; RESPONSIVENESS; STIMULATION; TACHYKININS;
Keywords:
bradykinin; histamine; methacholine; eosinophils; monocytes; C fibers; lung; plethysmography; ovalbumin; sensitization; aerosol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bergren, DR Creighton Univ, Sch Med, Dept Biomed Sci, 2500 Calif Plaza, Omaha, NE 68178 USA Creighton Univ 2500 Calif Plaza Omaha NE USA 68178 E 68178 USA
Citazione:
D.R. Bergren, "Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs", J APP PHYSL, 90(2), 2001, pp. 695-704

Abstract

Tobacco smoke (TS) exposure induces airway hyperreactivity, particularly in sensitive individuals with asthma. However, the mechanism of this airway hyperreactivity is not well understood. To investigate the relative susceptibility of atopic and nonatopic individuals to TS-induced airway hyperreactivity, we exposed ovalbumin (OA)-sensitized and nonsensitized guinea pigs to TS exposure (5 mg/l air, 30-min exposure, 7 days/wk for 120-156 days). Two similar groups exposed to compressed air served as controls. Airway reactivity was assessed as an increase in enhanced pause (Penh) units using a plethysmograph that allowed free movement of the animals. After 90 days of exposure, airway reactivity increased in OA-TS guinea pigs challenged with capsaicin, bradykinin, and neurokinin A fragment 4-10 aerosols. In addition, substance P content increased in lung perfusate of OA-TS guinea pigs in response to acute TS challenge compared with that of the other groups. Airway hyperirritability was not enhanced by phosphoramidon but was attenuated by a cocktail of neurokinin antagonists, nor was airway hyperreactivity observed after either methacholine or histamine challenge in OA-TS guinea pigs. Chronic TS exposure enhanced neither airway reactivity to histamine or methacholine nor contractility of isolated tracheal rings. In conclusion, chronic TS exposure increased airway reactivity to capsaicin and bradykinin aerosol challenge, and OA-TS guinea pigs were most susceptible to airway dysfunction as the result of exposure to TS compared with the other groups. Increased airway reactivity to capsaicin suggests a mechanism involving neurogenic inflammation, such as increased activation of lung C fibers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 13:11:25