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Titolo:
Training affects muscle phospholipid fatty acid composition in humans
Autore:
Helge, JW; Wu, BJ; Willer, M; Daugaard, JR; Storlien, LH; Kiens, B;
Indirizzi:
Univ Copenhagen, August Krogh Inst, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Univ Wollongong, Metab Res Ctr, Wollongong, NSW 2522, Australia Univ Wollongong Wollongong NSW Australia 2522 ongong, NSW 2522, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 670 - 677
SICI:
8750-7587(200102)90:2<670:TAMPFA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED CHANGES; HUMAN SKELETAL-MUSCLE; INSULIN-RECEPTOR; CELLS; RAT; SENSITIVITY; DETERMINANT; OXIDATION; GLYCOGEN; BINDING;
Keywords:
exercise; one-leg model; enzyme activity; fiber types; lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Helge, JW State Hosp, Copenhagen Muscle Res Ctr, Sect 7652, Blegdamsvej 9,DK-2100 Copenhagen O, Denmark State Hosp Blegdamsvej 9 Copenhagen DenmarkO nhagen O, Denmark
Citazione:
J.W. Helge et al., "Training affects muscle phospholipid fatty acid composition in humans", J APP PHYSL, 90(2), 2001, pp. 670-677

Abstract

Training improves insulin sensitivity, which in turn may affect performance by modulation of fuel availability. Insulin action, in turn, has been linked to specific patterns of muscle structural lipids in skeletal muscle. This study investigated whether regular exercise training exerts an effect onthe muscle membrane phospholipid fatty acid composition in humans. Seven male subjects performed endurance training of the knee extensors of one leg for 4 wk. The other leg served as a control. Before, after 4 days, and after 4 wk, muscle biopsies were obtained from the vastus lateralis. After 4 wk, the phospholipid fatty acid contents of oleic acid 18:1(n-9) and docosahexaenoic acid 22:6(n-3) were significantly higher in the trained (10.9 +/- 0.5% and 3.2 +/- 0.4% of total fatty acids, respectively) than the untrainedleg (8.8 +/- 0.5% and 2.6 +/- 0.4%, P < 0.05). The ratio between n-6 and n-3 fatty acids was significantly lower in the trained (11.1 +/- 0.9) than the untrained leg (13.1 +/- 1.2, P < 0.05). In contrast, training did not affect muscle triacylglycerol fatty acid composition. Citrate synthase activity was increased by 17% in the trained compared with the untrained leg (P <0.05). In this model, diet plays a minimal role, as the influence of dietary intake is similar on both legs. Regular exercise training per se influences the phospholipid fatty acid composition of muscle membranes but has no effect on the composition of fatty acids stored in triacylglycerols within the muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:03:48