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Titolo:
Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung
Autore:
Maron, MB; Fu, ZX; Mathieu-Costello, O; West, JB;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Physiol, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 Dept Physiol, Rootstown, OH 44272 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 638 - 648
SICI:
8750-7587(200102)90:2<638:EOHTPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS VASCULAR INDICATORS; PULMONARY CAPILLARIES; REFLECTION COEFFICIENT; STRESS FAILURE; PROTEIN PERMEABILITY; EDEMA; VOLUME;
Keywords:
blood-gas barrier; capillary wall stress; increased permeability edema; capillary filtration coefficient; osmotic reflection coefficient; barotrauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Maron, MB NE Ohio Univ, Coll Med, Dept Physiol, Rootstown, OH 44272 USA NEOhio Univ Rootstown OH USA 44272 ol, Rootstown, OH 44272 USA
Citazione:
M.B. Maron et al., "Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung", J APP PHYSL, 90(2), 2001, pp. 638-648

Abstract

To determine the correlation between ultrastructural and physiological changes in blood-gas barrier function in lungs transiently exposed to very high vascular pressures, we increased capillary transmural pressure (Ptm) of 6canine isolated perfused left lower lung lobe preparations (high-pressure group) to 80.3 Torr for 3.8 min and then determined the capillary filtration (K-fc) and osmotic reflection (sigma (d)) coefficients at a Ptm of 19.1 Torr in the ventilated lung lobes. This was followed by perfusion fixation of the lobes at a Ptm of 20.5 Torr for ultrastructural analysis. These data were compared with those obtained in six lobes in which Ptm was not transiently elevated before K-fc, sigma (d), and ultrastructural evaluation. K-fc was higher [0.249 +/- 0.042 (SE) vs. 0.054 +/- 0.009 g.min(-1).Torr(-1).100g(-1); P < 0.01] and <sigma>(d) was lower (0.52 +/- 0.07 vs. 0.85 +/- 0.08; P < 0.01) in the high-pressure group. In contrast, although endothelial and epithelial breaks were occasionally observed in some experiments, their incidence was not increased in the high-pressure group. These data suggest that the increased transvascular water and protein flux occurred through pathways of a size not resolvable by electron microscopy after vascular perfusion-fixation at a Ptm of 20.5 Torr.

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Documento generato il 18/01/21 alle ore 15:40:35