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Titolo:
Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats
Autore:
Warren, LE; Horwitz, BA; Hamilton, JS; Fuller, CA;
Indirizzi:
Univ Calif Davis, Div Biol Sci, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Physiol & Behav, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 606 - 614
SICI:
8750-7587(200102)90:2<606:EO2GOA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; ENERGY-EXPENDITURE; GENE-EXPRESSION; BODY-WEIGHT; PRODUCT; FATTY;
Keywords:
centrifugation; body mass; food intake; fat metabolism; gravity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Fuller, CA Univ Calif Davis, Div Biol Sci, Sect Neurobiol Physiol & Behav,1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CAUSA 95616 CA 95616 USA
Citazione:
L.E. Warren et al., "Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats", J APP PHYSL, 90(2), 2001, pp. 606-614

Abstract

Male Zucker rats were exposed to 2 G for 8 wk to test the hypothesis that the leptin regulatory pathway contributes to recovery from effects of 2 G on feeding, growth, and nutrient partitioning. After initial hypophagia, body mass-independent food intake of the lean rats exposed to 2 G surpassed that of the lean rats maintained at 1 G, but food intake of the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body mass and carcass fat were less in both genotypes. Leptin and percent fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not alter uncoupling protein-1 levels, it did elicit white fat pad-specific changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats, emphasizing the importance of a functional leptin regulatory pathway in this acclimation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 11:14:00