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Titolo:
Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects
Autore:
De Gouw, HWFM; Marshall-Partridge, SJ; Van der Veen, H; Van den Aardweg, JG; Hiemstra, PS; Sterk, J;
Indirizzi:
Leiden Univ, Med Ctr, Lung Funct Lab, Dept Pulm, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Clin Pharm & Toxicol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 586 - 592
SICI:
8750-7587(200102)90:2<586:RONOIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BRONCHOCONSTRICTION; L-ARGININE; REACTION SEQUENCE; RELAXING FACTOR; EXPIRED AIR; EXHALED AIR; BLOOD-FLOW; INHIBITION; HUMANS; LUNG;
Keywords:
exercise-induced bronchoconstriction; vascular leakage; exhaled nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sterk, J Leiden Univ, Med Ctr, Lung Funct Lab, Dept Pulm, C2-P,POB 9600, NL-2300 RCLeiden, Netherlands Leiden Univ C2-P,POB 9600 Leiden Netherlands NL-2300 RC herlands
Citazione:
H.W.F.M. De Gouw et al., "Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects", J APP PHYSL, 90(2), 2001, pp. 586-592

Abstract

A role of nitric oxide (NO) has been suggested in the airway response to exercise. However, it is unclear whether NO may act as a protective or a stimulatory factor. Therefore, we examined the role of NO in the airway response to exercise by using N-monomethyl-L-arginine (L-NMMA, an NO synthase inhibitor), L-arginine (the NO synthase substrate), or placebo as pretreatmentto exercise challenge in 12 healthy nonsmoking, nonatopic subjects and 12 nonsmoking, atopic asthmatic patients in a double-blind, crossover study. Fifteen minutes after inhalation of L-NMMA (10 mg), L-arginine (375 mg), or placebo, standardized bicycle ergometry was performed for 6 min using dry air, while ventilation was kept constant. The forced expiratory volume in 1-s response was expressed as area under the time-response curve (AUC) over 30 min. In healthy subjects, there was no significant change in AUC between L-NMMA and placebo treatment [28.6 +/- 17.0 and 1.3 +/- 20.4 (SE) for placebo and L-NMMA, respectively, P = 0.2]. In the asthmatic group, L-NMMA and L-arginine induced significant changes in exhaled NO (P < 0.01) but had no significant effect on AUC compared with placebo (geometric mean +/- SE: -204.3 +/- 1.5, -186.9 +/- 1.4, and -318.1 +/- 1.2%.h for placebo, L-NMMA, and L-arginine, respectively, P > 0.2). However, there was a borderline significant difference in AUC between L-NMMA and L-arginine treatment (P = 0.052). We conclude that modulation of NO synthesis has no effect on the airway response to exercise in healthy subjects but that NO synthesis inhibition slightly attenuates exercise-induced bronchoconstriction compared with NO synthase substrate supplementation in asthma. These data suggest that the net effect of endogenous NO is not inhibitory during exercise-induced bronchoconstriction in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:30:18