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Titolo:
Reflex cardiovascular responses originating in exercising muscles of mice
Autore:
Kramer, JM; Aragones, A; Waldrop, TG;
Indirizzi:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Integrat Physiol, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 579 - 585
SICI:
8750-7587(200102)90:2<579:RCROIE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; PRESSOR REFLEX; STATIC EXERCISE; CARDIORESPIRATORY REFLEXES; RESPIRATORY RESPONSES; RECEPTOR KNOCKOUT; CENTRAL PATHWAYS; CONTRACTION; VOLUNTARY; RATS;
Keywords:
mouse; muscle contraction; pressor reflex; genetic; hypoxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Waldrop, TG Univ Illinois, Dept Mol & Integrat Physiol, 524 Burrill Hall,407 S GoodwinAve, Urbana, IL 61801 USA Univ Illinois 524 Burrill Hall,407 S Goodwin Ave Urbana IL USA 61801
Citazione:
J.M. Kramer et al., "Reflex cardiovascular responses originating in exercising muscles of mice", J APP PHYSL, 90(2), 2001, pp. 579-585

Abstract

The cardiovascular responses induced by exercise are initiated by two primary mechanisms: central command and reflexes originating in exercising muscles. Although our understanding of cardiovascular responses to exercise in mice is progressing, a murine model of cardiovascular responses to muscle contraction has not been developed. Therefore, the purpose of this study wasto characterize the cardiovascular responses to muscular contraction in anesthetized mice. The results of this study indicate that mice demonstrate significant increases in blood pressure (13.8 +/- 1.9 mmHg) and heart rate 133.5 +/- 11.9 beats/min) to muscle contraction in a contraction-intensity-dependent manner, Mice also demonstrate 23.1 +/- 3.5, 20.9 +/- 4.0, 21.7 +/-2.6, and 25.8 +/- 3.0 mmHg increases in blood pressure to direct stimulation of tibial, peroneal, sural, and sciatic hindlimb somatic nerves, respectively. Systemic hypoxia (10% O-2-90% N-2) elicits increases in blood pressure (11.7 +/- 2.6 mmHg) and heart rate (42.7 +/- 13.9 beats/min), while increasing arterial pressure with phenylephrine decreases heart rate in a dose-dependent manner. The results from this study demonstrate the feasibility of using mice to study neural regulation of cardiovascular function during avariety of autonomic stimuli, including exercise-related drives such as muscle contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:45:08