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Titolo:
Enhanced synthesis of albumin and fibrinogen at high altitude
Autore:
Imoberdorf, R; Garlick, PJ; McNurlan, MA; Casella, GA; Peheim, E; Turgay, M; Bartsch, P; Ballmer, PE;
Indirizzi:
Univ Bern, Dept Internal Med, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 ternal Med, CH-3010 Bern, Switzerland Inselspital, Inst Chem Pathol, CH-3010 Bern, Switzerland Inselspital Bern Switzerland CH-3010 m Pathol, CH-3010 Bern, Switzerland Kantonsspital Winterthur, Med Klin, CH-8401 Winterthur, Switzerland Kantonsspital Winterthur Winterthur Switzerland CH-8401 hur, Switzerland SUNY Stony Brook, Dept Surg, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Surg, Stony Brook, NY 11794 USA Univ Heidelberg, Dept Sports Med, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 528 - 537
SICI:
8750-7587(200102)90:2<528:ESOAAF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSE EXERCISE PROTOCOL; ACUTE MOUNTAIN-SICKNESS; ACUTE-PHASE RESPONSE; PLASMA-VOLUME; PROTEIN-SYNTHESIS; SYNTHESIS RATES; CAPILLARY-PERMEABILITY; PULMONARY-EDEMA; BLOOD-VOLUME; HYPOXIA;
Keywords:
exercise; hypobaric hypoxia; respiratory alkalosis; plasma volume; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Imoberdorf, R Kantonsspital Winterthur, Med Klin, CH-8401 Winterthur, Switzerland Kantonsspital Winterthur Winterthur Switzerland CH-8401 nd
Citazione:
R. Imoberdorf et al., "Enhanced synthesis of albumin and fibrinogen at high altitude", J APP PHYSL, 90(2), 2001, pp. 528-537

Abstract

The acute effects of active and passive ascent to high altitude on plasma volume (PV) and rates of synthesis of albumin and fibrinogen have been examined. Measurements were made in two groups of healthy volunteers, initiallyat low altitude (550 m) and again on the day after ascent to high altitude(4,559 m). One group ascended by helicopter lair group, n = 8), whereas the other group climbed (foot group, n = 9), so that the separate contribution of physical exertion to the response could be delineated. PV was measuredby dilution of I-125-labeled albumin, whereas synthesis rates of albumin and fibrinogen were determined from the incorporation of isotope into protein after injection of [ring-H-2(5)]phenylalanine. In the air group, there was no change in PV at high altitude, whereas, in the foot group, there was a10% increase in PV (P < 0.01). Albumin synthesis(mg . kg(-1) . day(-1)) increased by 13% in the air group (P = 0.058) and by 32% in the foot group (P< 0.001). Fibrinogen synthesis (mg . kg(-1) .day(-1)) increased by 40% in the air group (P = 0.068) and by 100% in the foot group (P < 0.001). Hypoxia and alkalosis at high altitude did not differ between the groups. Plasma interleukin-6 was increased modestly in both groups but C-reactive protein was not changed in either group. It is concluded that increases in PV and plasma protein synthesis at high altitude result mainly from the physical exercise associated with climbing. However, a small stimulation of albumin and fibrinogen synthesis may be attributable to hypobaric hypoxia alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:59:54