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Titolo:
Decreased CSF pH at ventral brain stem induces widespread c-Fos immunoreactivity in rat brain neurons
Autore:
Douglas, RM; Trouth, CO; James, SD; Sexcius, LM; Kc, P; Dehkordi, O; Valladares, ER; McKenzie, C;
Indirizzi:
Howard Univ, Coll Med, Dept Physiol & Biophys, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 l & Biophys, Washington, DC 20059 USA Howard Univ, Coll Med, Dept Physiol, Washington, DC 20059 USA Howard UnivWashington DC USA 20059 ept Physiol, Washington, DC 20059 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 90, anno: 2001,
pagine: 475 - 485
SICI:
8750-7587(200102)90:2<475:DCPAVB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIOLATERAL CELL COLUMN; CENTRAL NERVOUS-SYSTEM; MEDULLA-OBLONGATA; LOCUS COERULEUS; PROJECTIONS; SURFACE; NUCLEUS; CHEMOSENSITIVITY; CHEMORECEPTORS; CONNECTIONS;
Keywords:
chemosensitivity; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Trouth, CO Howard Univ, Coll Med, Dept Physiol & Biophys, 520 W St NW, Washington, DC20059 USA Howard Univ 520 W St NW Washington DC USA 20059 on, DC20059 USA
Citazione:
R.M. Douglas et al., "Decreased CSF pH at ventral brain stem induces widespread c-Fos immunoreactivity in rat brain neurons", J APP PHYSL, 90(2), 2001, pp. 475-485

Abstract

Physiological evidence has indicated that central respiratory chemosensitivity may be ascribed to neurons located at the ventral medullary surface (VMS); however, in recent years, multiple sites have been proposed. Because c-Fos immunoreactivity is presumed to identify primary cells as well as second- and third-order cells that are activated by a particular stimulus, we hypothesized that activation of VMS cells using a known adequate respiratorystimulus, HI, would induce production of c-Fos in cells that participate in the central pH-sensitive respiratory chemoreflex loop. In this study, stimulation of rostral and caudal VMS respiratory chemosensitive sites in chloralose-urethane-anesthetized rats with acidic (pH 7.2) mock cerebrospinal fluid induced c-Fos protein immunoreactivity in widespread brain sites, suchas VMS, ventral pontine surface, retrotrapezoid, medial and lateral parabrachial, lateral reticular nuclei, cranial nerves VII and X nuclei, A(1) andC-1 areas, area postrema, locus coeruleus, and paragigantocellular nuclei. At the hypothalamus, the c-Fos reaction product was seen in the dorsomedial, lateral hypothalamic, supraoptic, and periventricular nuclei. These results suggest that 1) multiple c-Fos-positive brain stem and hypothalamic structures may represent part of a neuronal network responsive to cerebrospinal fluid pH changes at the VMS, and 2) VMS pH-sensitive neurons project to widespread regions in the brain stem and hypothalamus that include respiratory and cardiovascular control sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:28