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Titolo:
Physiological and genomic consequences of intermittent hypoxia - Selected Contribution: Chemoreflex responses to CO2 before and after an 8-h exposureto hypoxia in humans
Autore:
Fatemian, M; Robbins, PA;
Indirizzi:
Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1607 - 1614
SICI:
8750-7587(200104)90:4<1607:PAGCOI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTILATORY RESPONSE; CARBON-DIOXIDE; POIKILOCAPNIC HYPOXIA; RESPIRATORY CONTROL; STEP CHANGES; CATS; OXYGEN;
Keywords:
peripheral chemoreflex; central chemoreflex; multifrequency binary sequence; altitude; acclimatization; ventilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Robbins, PA Univ Oxford, Physiol Lab, Parks Rd, Oxford OX1 3PT, England Univ Oxford Parks Rd Oxford England OX1 3PT OX1 3PT, England
Citazione:
M. Fatemian e P.A. Robbins, "Physiological and genomic consequences of intermittent hypoxia - Selected Contribution: Chemoreflex responses to CO2 before and after an 8-h exposureto hypoxia in humans", J APP PHYSL, 90(4), 2001, pp. 1607-1614

Abstract

The ventilatory sensitivity to CO2, in hyperoxia, is increased after an 8-h exposure to hypoxia. The purpose of the present study was to determine whether this increase arises through an increase in peripheral or central chemosensitivity. Ten healthy volunteers each underwent 8-h exposures to 1) isocapnic hypoxia, with end-tidal P-O2 (PETO2) = 55 Torr and end-tidal PCO2 (PETCO2) = eucapnia; 2) poikilocapnic hypoxia, with PETO2 = 55 Torr and PETCO2 uncontrolled; and 3) air-breathing control. The ventilatory response to CO2 was measured before and after each exposure with the use of a multifrequency binary sequence with two levels of PETCO2: 1.5 and 10 Torr above the normal resting value. PETO2 was held at 250 Torr. The peripheral (Gp) and the central (Gc) sensitivities were calculated by fitting the ventilatory data to a two-compartment model. There were increases in combined Gp + Cc (26%, P < 0.05), Gp (33%, P < 0.01), and Gc (23%, P = not significant) after exposure to hypoxia. There were no significant differences between isocapnicand poikilocapnic hypoxia. We conclude that sustained hypoxia induces a significant increase in chemosensitivity to CO2 within the peripheral chemoreflex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:56:44