Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Physiological and genomic consequences of intermittent hypoxia - Invited Review: Physiological consequences of intermittent hypoxia: systemic blood pressure
Autore:
Fletcher, EC;
Indirizzi:
Univ Louisville, Sch Med, Div Resp Crit Care & Environm Med, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 onm Med, Louisville, KY 40292 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1600 - 1605
SICI:
8750-7587(200104)90:4<1600:PAGCOI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC EPISODIC HYPOXIA; OBSTRUCTIVE PULMONARY-DISEASE; SLEEP-APNEA; HYPERTENSION; ELEVATION; OXYGEN; RATS; ASSOCIATION; AROUSAL; TRIAL;
Keywords:
sleep apnea syndromes; anoxia; hypoxemia; hypertension; sympathetic nervous system; carotid chemoreceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, EC Univ Louisville, Sch Med, Div Resp Crit Care & Environm Med, Ambulatory Care Bldg,Rm A2L01,530 S Jackson St, Louisville, KY 40292 USA Univ Louisville Ambulatory Care Bldg,Rm A2L01,530 S Jackson St Louisville KY USA 40292
Citazione:
E.C. Fletcher, "Physiological and genomic consequences of intermittent hypoxia - Invited Review: Physiological consequences of intermittent hypoxia: systemic blood pressure", J APP PHYSL, 90(4), 2001, pp. 1600-1605

Abstract

One of the major manifestations of obstructive sleep apnea is profound andrepeated hypoxia during sleep. Acute hypoxia leads to stimulation of the peripheral chemoreceptors, which in turn increases sympathetic outflow, acutely increasing blood pressure. The chronic effect of these repeated episodic or intermittent periods of hypoxia in humans is difficult to study because chronic cardiovascular changes may take many years to manifest. Rodents have been a tremendous source of information in short- and long-term studiesof hyper tension and other cardiovascular diseases. Recurrent short cyclesof normoxia-hypoxia, when administered to rats for 35 days, allows examination of the chronic cardiovascular response to intermittent hypoxia patterned after the episodic desaturation seen in humans with sleep apnea. The result of this type of intermittent hypoxia in rats is a 10- to 14-mmHg increase in resting (unstimulated) mean blood pressure that lasts for several weeks after cessation of the daily cyclic hypoxia. Carotid body denervation, sympathetic nerve ablation, renal sympathectomy, adrenal medullectomy, and angiotensin II receptor blockade block the blood pressure increase. It appears that adrenergic and renin-angiotensin system overactivity contributes tothe early chronic elevated blood pressure in rat intermittent hypoxia and perhaps to human hypertension associated with obstructive sleep apnea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 15:19:57