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Titolo:
Effects of morphine and naloxone on fetal heart rate and movement in the pig
Autore:
Cohen, S; Parvizi, N; Mulder, EJH; Van Oord, HA; Jonker, FH; Van der Weijden, GC; Taverne, MAM;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3584 CL Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CL 3584 CL Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Obstet Neonatol & Gynecol, NL-3584 EA Utrecht,Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA -3584 EA Utrecht,Netherlands FAL, Inst Anim Sci & Anim Behav, Dept Physiol, D-31535 Neustadt, Germany FAL Neustadt Germany D-31535 av, Dept Physiol, D-31535 Neustadt, Germany
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1577 - 1583
SICI:
8750-7587(200104)90:4<1577:EOMANO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTORS; OVINE FETUS; SHEEP; BEHAVIOR; MODULATION; RESPONSES; PRESSURE; SOWS;
Keywords:
fetus; opioids; motility; ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Taverne, MAM Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Yalelaan 7, NL-3584 CL Utrecht, Netherlands Univ Utrecht Yalelaan 7 Utrecht NetherlandsNL-3584 CL lands
Citazione:
S. Cohen et al., "Effects of morphine and naloxone on fetal heart rate and movement in the pig", J APP PHYSL, 90(4), 2001, pp. 1577-1583

Abstract

To test the hypothesis that an increasing opioid tonus is involved in decreases in fetal heart rate (FHR) and movement (FM) during late gestation, westudied the effects of intravenous bolus injections of morphine ii mg) andnaloxone ii mg) on FHR and FM in the fetal pig. Twenty-one fetuses(1 per sow) were catheterized at 90-104 days of gestation (median 100 days). Recordings of FHR (electrocardiograph or Doppler-derived signals) and FM (ultrasonography) were made from 15 min before to 45 min after treatment. Morphine administration significantly decreased FHR, but it increased FHR variation and forelimb movements (LM). LM were clustered, and this stereotyped behavior has never before been observed in any mammalian fetus. Naloxone administration increased gross body movements and FHR without significant changes in FHR variation. It is concluded that FHR and motility are under opioidergic control in the pig fetus. Both morphine and naloxone induce hypermotility, suggesting that naloxone does not act as a pure opioid antagonist in the fetal pig.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:31:51