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Titolo:
Endotoxemia increases relative perfusion to dorsal-caudal lung regions
Autore:
Gerbino, AJ; Altemeier, WA; Schimmel, C; Glenny, RW;
Indirizzi:
Univ Washington, Dept Med, Div Pulm Crit Care Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Crit Care Med, Seattle, WA 98195 USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1508 - 1515
SICI:
8750-7587(200104)90:4<1508:EIRPTD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY BLOOD-FLOW; RESPIRATORY-DISTRESS SYNDROME; ESCHERICHIA-COLI ENDOTOXIN; VASCULAR-RESISTANCE; BODY POSITION; VENTILATION; SHEEP; VASOCONSTRICTION; MICROSPHERES; GRAVITY;
Keywords:
endotoxin; blood flow; heterogeneity; pulmonary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gerbino, AJ Univ Washington, Dept Med, Div Pulm Crit Care Med, BB-1253 Hlth Sci Bldg,Box 356522, Seattle, WA 98195 USA Univ Washington BB-1253 Hlth Sci Bldg,Box 356522 Seattle WA USA 98195
Citazione:
A.J. Gerbino et al., "Endotoxemia increases relative perfusion to dorsal-caudal lung regions", J APP PHYSL, 90(4), 2001, pp. 1508-1515

Abstract

Changes in the spatial distribution of perfusion during acute lung injury and their impact on gas exchange are poorly understood. We tested whether endotoxemia caused topographical differences in perfusion and whether these differences caused meaningful changes in regional ventilation-to-perfusion ratios and gas exchange. Regional ventilation and perfusion were measured in anesthetized, mechanically ventilated pigs in the prone position before and during endotoxemia with the use of aerosolized and intravenous fluorescent microspheres. On average, relative perfusion halved in ventral and cranial lung regions, doubled in caudal lung regions, and increased 1.5-fold in dorsal lung regions during endotoxemia. In contrast, there were no topographical differences in perfusion before endotoxemia and no topographical differences in ventilation at any time point. Consequently, endotoxemia increased regional ventilation-to-perfusion ratios in the caudal-to-cranial and dorsal-to-ventral directions, resulting in end-capillary Po, values that weresignificantly lower in dorsal-caudal than ventral-cranial regions. We conclude that there are topographical differences in the pulmonary vascular response to endotoxin that may have important consequences for gas exchange inacute lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:03:36