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Titolo:
Scoring of surface parameters of physiological relevance to surfactant therapy in respiratory distress syndrome
Autore:
Banerjee, R; Bellare, JR;
Indirizzi:
Indian Inst Technol, Dept Chem Engn, Bombay 400076, Maharashtra, India Indian Inst Technol Bombay Maharashtra India 400076 6, Maharashtra, India Indian Inst Technol, Sch Biomed Engn, Bombay 400076, Maharashtra, India Indian Inst Technol Bombay Maharashtra India 400076 6, Maharashtra, India
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1447 - 1454
SICI:
8750-7587(200104)90:4<1447:SOSPOP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC INTERFACIAL PROPERTIES; PROTEINS SP-B; PULMONARY SURFACTANT; LUNG SURFACTANT; DIPALMITOYL PHOSPHATIDYLCHOLINE; PHOSPHONOLIPID ANALOGS; EXCESS FILMS; SP-C; PHOSPHOLIPIDS; MONOLAYERS;
Keywords:
surface pressure; Wilhelmy balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bellare, JR Indian Inst Technol, Dept Chem Engn, Bombay 400076, Maharashtra, India Indian Inst Technol Bombay Maharashtra India 400076 ra, India
Citazione:
R. Banerjee e J.R. Bellare, "Scoring of surface parameters of physiological relevance to surfactant therapy in respiratory distress syndrome", J APP PHYSL, 90(4), 2001, pp. 1447-1454

Abstract

The Wilhelmy balance was used for in vitro testing of surface parameters of surfactants used for respiratory distress syndrome therapy. Two commercial protein-free surfactants, ALEC and Exosurf, were compared with pure formsof the three main phospholipids in natural surfactants, dipalmitoyl phosphatidylcholine (PC), phosphatidylglycerol (PG), and phosphatidylethanolamine(PE), and their binary mixtures, PC with PE and PG each in the ratio 2:3. Surface excess films (15 Angstrom (2)/molecule) were compressed at 1.2 cycles/min past collapse to a compression ratio of 4:1. The maximum surface pressure, spreading time, compressibility, respreading ratio, recruitment index, and hysteresis area were compared. A consolidated list of criteria for selection of suitable surfactants was compiled from the literature. A relative scoring system was devised for comparison based on these criteria. PC/PG(2:3) performed the best as it fulfilled all the criteria and obtained thehighest relative score. Exosurf also performed well, except on the respreading criterion. ALEC and PC/PE were equivalent in their performance and performed well, except on two criteria: hysteresis area and recruitment index. Thus the scoring system proposed here proved valuable to rate the overall efficacy as well as relative merits of surfactant formulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:11:24