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Titolo:
Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties
Autore:
Coombes, JS; Powers, SK; Rowell, B; Hamilton, KL; Dodd, SL; Shanely, RA; Sen, CK; Packer, L;
Indirizzi:
Univ Florida, Ctr Exercise Sci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 cise Sci, Gainesville, FL 32611 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA Univ Kuopio, Dept Physiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Physiol, FIN-70211 Kuopio, Finland
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1424 - 1430
SICI:
8750-7587(200104)90:4<1424:EOVEAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED OXIDATIVE STRESS; IN-VITRO DIAPHRAGM; N-ACETYLCYSTEINE; REACTIVE OXYGEN; FREE-RADICALS; CA2+ RELEASE; FATIGUE; ANTIOXIDANT; EXERCISE; SUPPLEMENTATION;
Keywords:
antioxidants; contraction; redox; oxidation; reactive oxygen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Coombes, JS Univ Queensland, Sch Human Movement Studies, Rm 520,Connell Bldg, St Lucia, Qld 4072, Australia Univ Queensland Rm 520,Connell Bldg St Lucia Qld Australia 4072
Citazione:
J.S. Coombes et al., "Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties", J APP PHYSL, 90(4), 2001, pp. 1424-1430

Abstract

Initial experiments were conducted using an in situ rat tibialis anterior (TA) muscle preparation to assess the influence of dietary antioxidants on muscle contractile properties. Adult Sprague-Dawley rats were divided into two dietary groups: 1) control diet (Con) and 2) supplemented with vitamin E (VE) and alpha -lipoic acid (alpha -LA) (Antiox). Antiox rats were fed the Con rats' diet (AIN-93M) with an additional 10,000 IU VE/kg diet and 1.65g/kg alpha -LA. After an 8-wk feeding period, no differences existed (P > 0.05) between the two dietary groups in maximum specific tension before or after a fatigue protocol or in force production during the fatigue protocol. However, in unfatigued muscle, maximal twitch tension and tetanic force production at stimulation frequencies less than or equal to 40 Hz were less (P < 0.05) in Antiox animals compared with Con. To investigate which antioxidant was responsible for the depressed force production, a second experiment was conducted using an in vitro rat diaphragm preparation. Varying concentrations of VE and dihydrolipoic acid, the reduced form of <alpha>-LA, were added either individually or in combination to baths containing diaphragmmuscle strips. The results from these experiments indicate that high levels of VE depress skeletal muscle force production at low stimulation frequencies.

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Documento generato il 04/04/20 alle ore 03:03:21