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Titolo:
Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle
Autore:
Smith, HK; Maxwell, L; Rodgers, CD; McKee, NH; Plyley, MJ;
Indirizzi:
Univ Auckland, Dept Exercise & Sport Sci, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 Sport Sci, Auckland 1, New Zealand Univ Auckland, Dept Pathol, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 ept Pathol, Auckland 1, New Zealand Univ Toronto, Fac Phys Educ & Hlth, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 Hlth, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Surg, Toronto, ON M5S 1A1, Canada Univ Toronto TorontoON Canada M5S 1A1 Surg, Toronto, ON M5S 1A1, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1407 - 1414
SICI:
8750-7587(200104)90:4<1407:ESCPAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLEUS MUSCLE; ECCENTRIC EXERCISE; INDUCED INJURY; ADULT-RATS; REGENERATION; ACTIVATION; HYPERTROPHY; EXPRESSION; DAMAGE; GROWTH;
Keywords:
eccentrically biased exercise; muscle injury; immunocytochemistry; fiber type; bromodeoxyuridine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, HK Univ Auckland, Dept Exercise & Sport Sci, Private Bag 92019, Auckland 1, New Zealand Univ Auckland Private Bag 92019 Auckland New Zealand 1 Zealand
Citazione:
H.K. Smith et al., "Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle", J APP PHYSL, 90(4), 2001, pp. 1407-1414

Abstract

The effects of increased functional loading on early cellular regenerativeevents after exercise-induced injury in adult skeletal muscle were examined with the use of in vivo labeling of replicating myofiber nuclei and immunocyto- and histochemical techniques. Satellite cell proliferation in the soleus (Sol) of nonexercised rats (0.4 +/- 0.2% of fibers) was unchanged after an initial bout of declined treadmill exercise but was elevated after two(1.0 +/- 0.2%, P less than or equal to 0.01), but not four or seven, dailybouts of the same task. Myonuclei produced over the 7-day period comprised0.9-1.9% of myonuclei in isolated fibers of Sol, tibialis anterior, and vastus intermedius of nonexercised rats. The accretion of new myonuclei was enhanced (P less than or equal to 0.05) in Sol and vastus intermedius by theinitial exercise followed by normal activity (to 3.1-3.4% of myonudei) andmore so by continued daily exercise (4.2-5.3%). Observed coincident with alower incidence of histological fiber injury and unchanged fiber diameter and myonuclei per millimeter, the greater new myonuclear accretion induced by continued muscle loading may contribute to an enhanced fiber repair and regeneration after exercise-induced injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:37:58