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Titolo:
Endurance training alters outward K+ current characteristics in rat cardiocytes
Autore:
Jew, KN; Olsson, MC; Mokelke, EA; Palmer, BM; Moore, RL;
Indirizzi:
Univ Colorado, Dept Kinesiol & Appl Physiol, Cardiovasc Inst, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 Cardiovasc Inst, Boulder, CO 80309 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1327 - 1333
SICI:
8750-7587(200104)90:4<1327:ETAOKC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR MYOCYTES; TRANSIENT OUTWARD; EXERCISE; CHANNEL; EXPRESSION; MYOCARDIUM; KV4.3;
Keywords:
action potential; potassium currents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Jew, KN Univ Colorado, Dept Kinesiol & Appl Physiol, Cardiovasc Inst, Campus Box 354, Boulder, CO 80309 USA Univ Colorado Campus Box 354 Boulder CO USA 80309 er, CO 80309 USA
Citazione:
K.N. Jew et al., "Endurance training alters outward K+ current characteristics in rat cardiocytes", J APP PHYSL, 90(4), 2001, pp. 1327-1333

Abstract

The effect of endurance run training on outward K+ currents with rapidly inactivating (I-to) and sustained or slowly inactivating (I-sus) characteristics was examined in left ventricular (LV) cardiocytes isolated from sedentary (Sed) and treadmill-trained (Tr) female Sprague-Dawley rats. Iso lated LV cardiocytes were used in whole cell patch-clamp studies to characterize whole cell I-to and I-sus. Peak I-to was greatest in cells isolated from the Tr group. When I-to was corrected for cell capacitance to yield a currentdensity, most, but not all, of the Sed vs. Tr differences in I-to magnitude were eliminated. Regardless of how I-to was expressed (e.g., I,, or I-to density), the time required to achieve a peak value was markedly shortened in the cardiocytes isolated from the Tr group. Training elicited a reduction in I-to, density. Action potential characteristics were determined in Sedand Tr cardiocytes in primary culture. Training did not affect resting membrane potential, whereas peak membrane potential was reduced and time to peak membrane potential was prolonged in the Tr group. In addition, time to 50% repolarization was signiticantly increased in cells from the Tr group. Collectively, these data indicate that I-to and I-sus characteristics are altered by training in isolated LV cardiocytes. These alterations in I-to andI-sus may be responsible, at least in part, for the training-induced alterations in action potential configuration in cardiocytes in primary culture.

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Documento generato il 26/01/20 alle ore 09:56:46