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Titolo:
Lactate removal is not enhanced in nonstimulated perfused skeletal muscle after endurance training
Autore:
Sumida, KD; Donovan, CM;
Indirizzi:
Univ So Calif, Dept Kinesiol, Los Angeles, CA 90089 USA Univ So Calif LosAngeles CA USA 90089 inesiol, Los Angeles, CA 90089 USA Chapman Unvi, Dept Biol Sci, Orange, CA 92866 USA Chapman Unvi Orange CA USA 92866 nvi, Dept Biol Sci, Orange, CA 92866 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1307 - 1313
SICI:
8750-7587(200104)90:4<1307:LRINEI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE; GLUCONEOGENESIS; METABOLISM; INTENSITY; CLEARANCE; KINETICS;
Keywords:
lactate oxidation; fiber types; glyconeogenesis; [C-14]lactate; [C-14]glycogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Donovan, CM Univ So Calif, Dept Kinesiol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Angeles, CA 90089 USA
Citazione:
K.D. Sumida e C.M. Donovan, "Lactate removal is not enhanced in nonstimulated perfused skeletal muscle after endurance training", J APP PHYSL, 90(4), 2001, pp. 1307-1313

Abstract

The effects of endurance braining (running 40 m/min, 10% grade for 60 min,5 days/wk for 8 wk) on skeletal muscle lactate removal was studied in ratsby utilizing the isolated hindlimb perfusion technique. Hindlimbs were perfused (single-pass) with Krebs-Henseleit bicarbonate buffer, fresh bovine erythrocytes (hematocrit similar to 30%), 10 mM lactate, and [U-C-14]lactate(30,000 dpm/ml). Arterial and venous blood samples were collected every 10min for the duration of the experiment to assess lactate uptake. During perfusions, no significant differences in skeletal muscle lactate uptake wereobserved between trained (7.31 +/- 0.20 mu mol/min) and control hindlimbs (6.98 +/- 0.43 mu mol/min). In support, no significant differences were observed for [C-14]lactate uptake in trained (22,776 +/- 370 dpm/min) comparedwith control hindlimbs (21,924 +/- 1,373 dpm/min). Concomitant with these observations, no significant differences were observed between groups for oxygen consumption (4.93 +/- 0.18 vs. 4.92 +/- 0.13 mu mol/min), net skeletal muscle glycogen synthesis (7.1 +/- 0.4 vs. 6.5 +/- 0.3 mu mol.40 min(-1).g(-1)), or (CO2)-C-14 production (2.203 +/- 185 vs. 2,098 +/- 155 dpm/min),trained and control, respectively. These findings indicate that endurance training does not affect lactate uptake or alter the metabolic fate of lactate in quiescent skeletal muscle.

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Documento generato il 29/03/20 alle ore 12:18:37