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Titolo:
Generation of oxidative stress contributes to the development of pulmonaryhypertension induced by hypoxia
Autore:
Hoshikawa, Y; Ono, S; Suzuki, S; Tanita, T; Chida, M; Song, C; Noda, M; Tabata, T; Voelkel, NF; Fujimura, S;
Indirizzi:
Tohoku Univ, Inst Dev Aging & Canc, Dept Thorac Surg, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 i & Crit Care Med, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1299 - 1306
SICI:
8750-7587(200104)90:4<1299:GOOSCT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING FACTOR; FACTOR PAF-ACETHER; XANTHINE-OXIDASE; OXYGEN-TOXICITY; TISSUE-INJURY; FREE-RADICALS; RATS; HYDROPEROXIDE; ANTAGONISTS; INHIBITION;
Keywords:
N-acetylcysteine; phosphatidylcholine hydroperoxide; xanthine oxidase; allopurinol; pulmonary vascular remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hoshikawa, Y Tohoku Univ, Inst Dev Aging & Canc, Dept Thorac Surg, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan Tohoku Univ 4-1 Seiryo Machi Sendai Miyagi Japan 9808575 apan
Citazione:
Y. Hoshikawa et al., "Generation of oxidative stress contributes to the development of pulmonaryhypertension induced by hypoxia", J APP PHYSL, 90(4), 2001, pp. 1299-1306

Abstract

Chronic hypoxia causes pulmonary hypertension and right ventricular hypertrophy associated with pulmonary vascular remodeling. Because hypoxia might promote generation of oxidative stress in vivo, we hypothesized that oxidative stress may play a role in the hypoxia-induced cardiopulmonary changes and examined the effect of treatment with the antioxidant N-acetylcysteine (NAC) in rats. NAC reduced hypoxia-induced cardiopulmonary alterations at 3 wk of hypoxia. Lung phosphatidylcholine hydroperoxide (PCOOH) increased at days I and 7 of the hypoxic exposure, and NAC attenuated the increase in lung PCOOH. Lung xanthine oxidase (XO) activity was elevated from day 1 through day 21 especially during the initial 3 days of the hypoxic exposure. TheXO inhibitor allopurinol significantly inhibited the hypoxia-induced increase in lung PCOOH and pulmonary hypertension, and allopurinol treatment only for the initial 3 days also reduced the hypoxia-induced right ventricularhypertrophy and pulmonary vascular thickening. These results suggest that oxidative stress produced by activated XO in the induction phase of hypoxicexposure contributes to the development of chronic hypoxic pulmonary hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:50:12