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Titolo:
Regional differences in intramyocellular lipids in humans observed by in vivo H-1-MR spectroscopic imaging
Autore:
Hwang, JH; Pan, JW; Heydari, S; Hetherington, HP; Stein, DT;
Indirizzi:
Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Dept Med, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA Albert EinsteinColl Med Bronx NY USA 10461 t Neurol, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Radiol, Bronx, NY 10461 USA Albert EinsteinColl Med Bronx NY USA 10461 t Radiol, Bronx, NY 10461 USA Brookhaven Natl Lab, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA11973 aven Natl Lab, Upton, NY 11973 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1267 - 1274
SICI:
8750-7587(200104)90:4<1267:RDIILI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; MAGNETIC-RESONANCE SPECTROSCOPY; DIFFERENT FIBER TYPES; IN-VIVO; INSULIN-RESISTANCE; TRIGLYCERIDE STORES; TOTAL CREATINE; EXERCISE; SENSITIVITY; H-1-NMR;
Keywords:
magnetic resonance spectroscopy; triglyceride; quantification; phosphocreatine; body composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hwang, JH Albert Einstein Coll Med, Dept Med, Rm G47,1300 Morris Pk Ave, Bronx, NY 10461 USA Albert Einstein Coll Med Rm G47,1300 Morris Pk Ave BronxNY USA 10461
Citazione:
J.H. Hwang et al., "Regional differences in intramyocellular lipids in humans observed by in vivo H-1-MR spectroscopic imaging", J APP PHYSL, 90(4), 2001, pp. 1267-1274

Abstract

Regional differences in the content of intramyocellu lar lipids (IMCL), extramyocellular lipids, and total creatine (TCr) were quantified in soleus (S), tibialis posterior (TP), and tibialis anterior (TA) muscles in humans using in vivo H-1 proton spectroscopic imaging at 4 T. Improved spatial resolution (0.25-ml nominal voxel resolution) made it feasible to measure IMCL in S, TP, and TA simultaneously in vivo. The most significant regional difference was found in the content of IMCL compared with extramyocellular lipids or TCr. The concentrations of TCr were found to be 29-32 mmol/kg, with little regional variation. IMCL content was measured to be 4.8 +/- 1.6 mmol/kg tissue wt in S, 2.8 +/- 1.3 mmol/kg tissue wt in TP, and 1.6 +/- 0.9 mmol/kg tissue wt in TA in the order of S > TP > TA (P < 0.05). It is likely that these IMCL values are consistent with the known fiber types of these muscles, with S having the greatest fraction of type I (slow-twitch, oxidative) fibers and TA having a large fraction of type IIb (fast-twitch, glycolytic) fibers.

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Documento generato il 25/01/20 alle ore 09:44:21