Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of smooth muscle activation on axial mechanical properties of excised canine bronchi
Autore:
Shardonofsky, FR; Officer, TM; Boriek, AM; Rodarte, JR;
Indirizzi:
Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA Baylor Coll Med, Dept Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Med, Dept Med, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1258 - 1266
SICI:
8750-7587(200104)90:4<1258:EOSMAO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG; HISTAMINE; AIRWAYS; VOLUME; ORIENTATION; INVITRO; LENGTH; TREE;
Keywords:
elastance; compliance; lung recoil; bronchoconstriction; pulmonary mechanics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Shardonofsky, FR Baylor Coll Med, Texas Childrens Hosp, Sect Pediat Pulm, 6621 Fannin,MC 3-2571, Houston, TX 77030 USA Baylor Coll Med 6621 Fannin,MC3-2571 Houston TX USA 77030
Citazione:
F.R. Shardonofsky et al., "Effects of smooth muscle activation on axial mechanical properties of excised canine bronchi", J APP PHYSL, 90(4), 2001, pp. 1258-1266

Abstract

This study tested the hypothesis that airway smooth muscle (ASM) activation produces an airway active axial force (AAAF). Bronchi (n = 10) immersed in a tissue bath containing 95% O-2-5% CO2-equilibrated Krebs solution were subjected to passive axial lengthening and shortening at 0-20 cmH(2)O of transmural pressure. ASM was relaxed with isoproterenol and activated with methacholine. Axial tensile (Ex), transverse compressive (is an element ofy),and shear strains (is an element of xy) Were computed from the displacements of four markers placed onto the specimen's surface. The AAAF was estimated by subtracting the control axial force (AF) values at a given ex from those obtained after methacholine. Ex-AF relationships were curvilinear, withmaximum uc being approached at similar to 15 g of AF. The Ey decreased during bronchial lengthening. Cholinergic stimulation produced I) a decrease of both Ex and Ey at a given AF relative to control, indicating ASM shortening, and 2) an AAAF that increased with increasing Ex and transmural pressure. A portion of the work of expanding the lungs is required to lengthen theairways; therefore, an AAAF would increase lung elastance and recoil.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:38:11