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Titolo:
Angiogenin gene-race interaction for resting and exercise BP phenotypes: the HERITAGE Family Study
Autore:
Rivera, MA; Echegaray, M; Rankinen, T; Perusse, L; Rice, T; Gagnon, J; Leon, AS; Skinner, JS; Wilmore, JH; Rao, DC; Bouchard, C;
Indirizzi:
Univ Puerto Rico, Sch Med, Dept Phys Med Rehabil & Sports Med, San Juan, PR 00936 USA Univ Puerto Rico San Juan PR USA 00936 Sports Med, San Juan, PR 00936 USA Univ Puerto Rico, Sch Med, Dept Physiol, San Juan, PR 00936 USA Univ Puerto Rico San Juan PR USA 00936 pt Physiol, San Juan, PR 00936 USA Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA Pennington Biomed ResCtr Baton Rouge LA USA 70808 on Rouge, LA 70808 USA Univ Laval, Phys Act Sci Lab, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 Quebec City, PQ G1K 7P4, Canada Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA Univ Minnesota, Sch Kinesiol & Leisure Studies, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 tudies, Minneapolis, MN 55455 USA Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 Kinesiol, Bloomington, IN 47405 USA Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 nesiol, College Stn, TX 77843 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1232 - 1238
SICI:
8750-7587(200104)90:4<1232:AGIFRA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY RAREFACTION; SKELETAL-MUSCLE; HUMAN-TUMOR; HYPERTENSION; REPRODUCIBILITY; PROSTACYCLIN; POLYMORPHISM; SEQUENCE; RNA;
Keywords:
genetics; AvaII; African Americans; acute exercise; endurance exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rivera, MA Univ Puerto Rico, Sch Med, Dept Phys Med Rehabil & Sports Med, Main Bldg,Off A-204, San Juan, PR 00936 USA Univ Puerto Rico Main Bldg,Off A-204 San Juan PR USA 00936 USA
Citazione:
M.A. Rivera et al., "Angiogenin gene-race interaction for resting and exercise BP phenotypes: the HERITAGE Family Study", J APP PHYSL, 90(4), 2001, pp. 1232-1238

Abstract

We examined the association between an angiogenin gene polymorphism and blood pressure (BP) at rest and in response to acute exercise before and after a 20-wk endurance-training program. Subjects were 737 normotensive and borderline hypertensive subjects (257 black and 480 white). The poly morphismwas detected by PCR and digestion with Av alpha II, yielding an allele of 253 bp or a rare allele of 194 + 59 bp. Resting and exercise [50 W; 60, 80,and 100% of maximal O-2 consumption (V-O2 (max))] systolic (SBP) and diastolic BP were determined before and after training. Among blacks, adjusted SEP in the sedentary state was significantly lower in carriers of the rare allele at rest and exercise intensities of 60, 80, and 100% of V-O2 max. In the trained state, carriers of the rare allele had a significantly (P < 0.05) lower SBP than did noncarriers at rest and at 80 and 100% of V-O2 max. The genotypic effect observed among blacks was not evident among whites. Furthermore, change in BP (after - before) was not significantly associated with the genotype. In conclusion, the angiogenin gene Au<alpha>II polymorphism is associated with a lower SBP at rest and in response to acute high-intensity exercise in blacks but not in whites.

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Documento generato il 28/03/20 alle ore 22:59:22