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Titolo:
Hormonal regulation of PGE(2) and COX-2 production in rabbit uterine cervical fibroblasts
Autore:
Sato, T; Michizu, H; Hashizume, K; Ito, A;
Indirizzi:
Tokyo Univ Pharm & Life Sci, Dept Biochem, Tokyo 1920392, Japan Tokyo UnivPharm & Life Sci Tokyo Japan 1920392 em, Tokyo 1920392, Japan Natl Inst Anim Ind, Lab Reprod Endocrinol, Tsukuba, Ibaraki 3050901, JapanNatl Inst Anim Ind Tsukuba Ibaraki Japan 3050901 , Ibaraki 3050901, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1227 - 1231
SICI:
8750-7587(200104)90:4<1227:HROPAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN G/H SYNTHASE; NECROSIS-FACTOR-ALPHA; EPIDERMAL GROWTH-FACTOR; RAT MESANGIAL CELLS; GENE-EXPRESSION; MESSENGER-RNA; WISH CELLS; PREGNANT RABBITS; STEROID-HORMONES; ARACHIDONIC-ACID;
Keywords:
pregnancy; uterine contraction; parturition; labor; prostaglandin E-2; cyclooxygenase-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, T Tokyo Univ Pharm & Life Sci, Dept Biochem, 1432-1 Horinouchi, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci 1432-1 Horinouchi Tokyo Japan1920392
Citazione:
T. Sato et al., "Hormonal regulation of PGE(2) and COX-2 production in rabbit uterine cervical fibroblasts", J APP PHYSL, 90(4), 2001, pp. 1227-1231

Abstract

Prostaglandins (PGs) cause uterine contraction to initiate labor at term. We investigated the effect of progesterone and 17 beta -estradiol on the production of PGE(2) in rabbit uterine cervical fibroblasts. When the cervical fibroblasts were treated with interleukin-1 alpha (IL-1 alpha), the levelof PGE, was augmented in a time- and dose-dependent manner. The IL-1 alpha-augmented PGE, level was almost completely suppressed by progesterone and17 beta -estradiol at the physiological concentration (0.01 muM), whereas a slight decrease in the basal level of PGE, was observed in the cervical fibroblasts treated with both hormones at a pharmacological concentration (1muM). In addition, the level of PGE(2) augmented by IL-1 alpha was due to the increase of cyclooxygenase (COX) activity, which was inhibited by progesterone and 17 beta -estradiol as well as by indomethacin and a specific COX-2 inhibitor, NS-398, but not by the well-known COX-1 inhibitor, aspirin. Furthermore, progesterone and 17 beta -estradiol suppressed the IL-lu-augmented COX-2 production but not the constitutive production of COX-1 in rabbit uterine cervical fibroblasts. These results suggest that progesterone and17 beta -estradiol prevent the initiation of labor by inhibiting PGE(2) production after the suppression of COX-2 production during pregnancy in the rabbit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:54:38