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Titolo:
Respiratory control in humans after 8 h of lowered arterial Po-2, hemodilution, or carboxyhemoglobinemia
Autore:
Ren, XH; Dorrington, KL; Robbins, PA;
Indirizzi:
Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 1189 - 1195
SICI:
8750-7587(200104)90:4<1189:RCIHA8>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTILATORY RESPONSE; CARBON-MONOXIDE; CAROTID-BODY; HUMAN-BLOOD; HYPOXIA; ACCLIMATIZATION; CO; ALTITUDE;
Keywords:
hypoxia; carbon monoxide; ventilation; oxygen content;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Robbins, PA Univ Oxford, Physiol Lab, Parks Rd, Oxford OX1 3PT, England Univ Oxford Parks Rd Oxford England OX1 3PT OX1 3PT, England
Citazione:
X.H. Ren et al., "Respiratory control in humans after 8 h of lowered arterial Po-2, hemodilution, or carboxyhemoglobinemia", J APP PHYSL, 90(4), 2001, pp. 1189-1195

Abstract

In humans exposed to 8 h of isocapnic hypoxia, there is a progressive increase in ventilation that is associated with an increase in the ventilatory sensitivity to acute hypoxia. To determine the relative roles of lowered arterial Po-2 and oxygen content in generating these changes, the acute hypoxic ventilatory response was determined in 11 subjects after four 8-h exposures: 1) protocol IH (isocapnic hypoxia), in which end-tidal Po-2 was held at 55 Torr and end-tidal Pco(2) was maintained at the preexposure value; 2) protocol PB (phlebotomy), in which 500 ml of venous blood were withdrawn; 3) protocol CO, in which carboxyhemoglobin was maintained at 10% by controlled carbon monoxide inhalation; and 4) protocol C as a control. Both hypoxicsensitivity and ventilation in the absence of hypoxia increased significantly after protocol IH (P < 0.001 and P < 0.005, respectively, ANOVA) but not after the other three protocols. This indicates that it is the reduction in arterial Po-2 that is primarily important in generating the increase in the acute hypoxic ventilatory response in prolonged hypoxia. The associatedreduction in arterial oxygen content is unlikely to play an important role.

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Documento generato il 04/04/20 alle ore 02:59:47