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Titolo:
Nucleoside reverse transcriptase inhibitor resistance
Autore:
Loveday, C;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Retrovirol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
, volume: 26, anno: 2001, supplemento:, 1
pagine: S10 - S24
SICI:
1525-4135(20010301)26:<S10:NRTIR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ZIDOVUDINE COMBINATION THERAPY; ANTIRETROVIRAL-NAIVE PATIENTS; PLACEBO-CONTROLLED TRIAL; HIGH-LEVEL RESISTANCE; AIDS-RELATED COMPLEX; DRUG-RESISTANCE; CUBIC MILLIMETER; DNA-SYNTHESIS; HIV-1-INFECTED PATIENTS;
Keywords:
NRTI resistance; reverse transcriptase enzyme; mutations; multiple-drug resistance; M184V;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Loveday, C Royal Free & Univ Coll Med Sch, Dept Retrovirol, Royal Free Campus,RowlandHill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
C. Loveday, "Nucleoside reverse transcriptase inhibitor resistance", J ACQ IMM D, 26, 2001, pp. S10-S24

Abstract

Nucleoside reverse transcriptase inhibitors (NRTIs) comprise the first class of drug with proven antiretroviral efficacy against HIV-1, and the firstin which drug resistance was reported. Ongoing research in the area of NRTI resistance and cross-resistance contributes much to what we know about the failure of antiretroviral therapy. The genetic mutation patterns responsible for resistance to the available NRTIs have been well documented. This information is being used to plan rational drug therapy. Furthermore, it serves as the standard against which to evaluate response patterns to multiple-drug regimens, ultimately enabling more accurate prediction of outcome with combination therapies. Other features of NRTI resistance, such as the theoretic reversal of zidovudine resistance associated with the M184V mutationor the powerful influence of the Q151M multiple-drug resistance mutation, have revealed the unpredictable nature of HIV resistance and how much we still need to learn. Although NRTIs are the cornerstone of antiretroviral therapy at present and are used to control disease progression for extended periods, it is clear that eventually resistance occurs with all antiretroviral regimens. Future research into NRTI-resistance mutations, mutational interactions, treatment sequencing, and viral fitness and fidelity will continue to refine our understanding of drug resistance and improve our ability todelay or eliminate resistance and advance HN control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:25:53