Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a mew cardioselective Ca2+ channel blocker, in conscious dogs
Autore:
Takahara, A; Dohmoto, H; Yoshimoto, R; Sugiyama, A; Hashimoto, K;
Indirizzi:
Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan Ajinomoto Co Inc Kawasaki Kanagawa Japan 2108681 Kanagawa 2108681, Japan Yamanashi Med Univ, Dept Pharmacol, Tamaho, Yamanashi 4093898, Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 85, anno: 2001,
pagine: 331 - 334
SICI:
0021-5198(200103)85:3<331:UOTSTA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIVO CANINE MODEL; ANTIARRHYTHMIC DRUG; BLOOD-PRESSURE; CALCIUM; PROPRANOLOL; VALIDATION; HALOTHANE;
Keywords:
AH-1058; Ca2+ channel blocker; cardiovascular action;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Takahara, A Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki Ku, 1-1 Suzukicho, Kawasaki, Kanagawa 2108681, Japan Ajinomoto Co Inc 1-1 Suzuki cho Kawasaki Kanagawa Japan 2108681
Citazione:
A. Takahara et al., "Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a mew cardioselective Ca2+ channel blocker, in conscious dogs", JPN J PHARM, 85(3), 2001, pp. 331-334

Abstract

Cardiovascular effects of a new Ca2+ channel blocker AH-1058, 4-(5H-dibenzo[a,d]cyclo-hepten-5-ylidene)-1-[(E)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride, were assessed in conscious dogs using a new telemetry system. AH-1058 (0.03, 0.1 and 0.3 mg/kg, i.v.) reduced systolic blood pressure and the maximal upstroke velocity of the left ventricular pressure and increased the heart rate in a dose-dependent manner without affecting the diastolic blood pressure; each of these responses lasted for several hours. These results support the previous knowledge that AH-1058 is a long-lasting cardiodepressive drug. The telemetry system provided important information for predicting favorable clinical effects of AH-1058.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:56:36