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Titolo:
Comparison of noradrenergic and serotonergic antidepressants in reducing immobility time in the tail suspension test
Autore:
Fujishiro, J; Imanishi, T; Baba, J; Kosaka, K;
Indirizzi:
Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Meiji Seika Kaisha Ltd, Pharmaceut Res Ctr, Kohoku Ku, Yokohama, Kanagawa 2228567, Japan Meiji Seika Kaisha Ltd Yokohama Kanagawa Japan 2228567 awa 2228567, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 85, anno: 2001,
pagine: 327 - 330
SICI:
0021-5198(200103)85:3<327:CONASA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; FLUVOXAMINE; INHIBITORS; RATS;
Keywords:
tail suspension test; antidepressant; immobility time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Fujishiro, J Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fukuura Yokohama Kanagawa Japan 2360004
Citazione:
J. Fujishiro et al., "Comparison of noradrenergic and serotonergic antidepressants in reducing immobility time in the tail suspension test", JPN J PHARM, 85(3), 2001, pp. 327-330

Abstract

We examined the effects of two noradrenergic tricyclic antidepressants andtwo selective serotonin re-uptake inhibitors in the tail suspension test, with a suspension period of 30 min instead of the usual 10 min. Within the first 10 min, desipramine, nortriptyline and fluvoxamine significantly reduced the duration of immobility. Whereas desipramine and nortriptyline were also efficacious in the rest of the test period, fluvoxamine was not. Fluoxetine showed no significant effect throughout the study period. These results suggest that a prolonged tail suspension test results in functional changes in the noradrenergic and serotonergic systems and alters the sensitivity to antidepressants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:35:32