Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prognostic score for patients with localized renal cell carcinoma treated by nephrectomy
Autore:
Nativ, O; Sabo, E; Madeb, R; Halachmi, S; Madjar, S; Moskovitz, B;
Indirizzi:
Bnai Zion Med Ctr, Dept Urol, IL-31048 Haifa, Israel Bnai Zion Med Ctr Haifa Israel IL-31048 ept Urol, IL-31048 Haifa, Israel Lady Davis Carmel Med Ctr, Dept Pathol, Haifa, Israel Lady Davis Carmel Med Ctr Haifa Israel Ctr, Dept Pathol, Haifa, Israel
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 1, volume: 3, anno: 2001,
pagine: 24 - 27
SICI:
1565-1088(200101)3:1<24:PSFPWL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MORPHOMETRY; MORPHOLOGIC PARAMETERS; INTERLEUKIN-2; INDICATORS; DNA;
Keywords:
kidney neoplasm; independent variable for survival; univariate and multivariate analysis; flow cytometry; nuclear morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nativ, O Bnai Zion Med Ctr, Dept Urol, POB 4940, IL-31048 Haifa, Israel Bnai Zion Med Ctr POB 4940 Haifa Israel IL-31048 8 Haifa, Israel
Citazione:
O. Nativ et al., "Prognostic score for patients with localized renal cell carcinoma treated by nephrectomy", ISR MED ASS, 3(1), 2001, pp. 24-27

Abstract

Objective: To evaluate the feasibility of using combined clinical and histomorphometric features to construct a prognostic score for the individual patient with localized renal cell carcinoma. Patients and Methods: We studied 39 patients with pT1 and pT2 RCC who underwent radical nephrectomy between 1974 and 1983. Univariate and multivariate analyses were used to determine the association between various prognostic features and patient survival. Results: The most important and independent predictors of survival were tumor angiogenesis (P = 0.009), nuclear DNA ploidy (P = 0.0071), mean nucleararea (P = 0.013), and mean elongation factor (P = 0.0346). Combination of these variables enabled prediction of outcome for the individual patient ata sensitivity and specificity of 78% and 89%, respectively. Conclusion: Our results indicate that no single parameter can accurately predict the outcome for patients with localized RCC. Combination of neovascularity, DNA content and morphometric shape descriptors enabled a more precise stratification of the patients into different risk categories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 17:48:11