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Titolo:
Evaluation of C-reactive protein, fibrinogen and antithrombin-III as risk factors for coronary artery disease
Autore:
Cavusoglu, Y; Gorenek, B; Alpsoy, S; Unalir, A; Ata, N; Timuralp, B;
Indirizzi:
Osmangazi Univ, Dept Cardiol, Eskisehir, Turkey Osmangazi Univ EskisehirTurkey i Univ, Dept Cardiol, Eskisehir, Turkey
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 1, volume: 3, anno: 2001,
pagine: 13 - 16
SICI:
1565-1088(200101)3:1<13:EOCPFA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; UNSTABLE ANGINA; HEART-DISEASE; ATHEROSCLEROTIC PLAQUES; PLASMA-FIBRINOGEN; PROGNOSTIC VALUE; INFLAMMATION; ASSOCIATION; PECTORIS; RUPTURE;
Keywords:
C-reactive protein; fibrinogen; antithrombin-III; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Cavusoglu, Y Osmangazi Univ, Dept Cardiol, Eskisehir, Turkey Osmangazi Univ Eskisehir Turkey Cardiol, Eskisehir, Turkey
Citazione:
Y. Cavusoglu et al., "Evaluation of C-reactive protein, fibrinogen and antithrombin-III as risk factors for coronary artery disease", ISR MED ASS, 3(1), 2001, pp. 13-16

Abstract

Background: inflammation is an important feature of atherosclerotic lesions and increased production of the acute-phase reactant. The contribution ofcoagulation factor to the development of coronary artery disease has not yet been clearly established. Objectives: To test whether C-reactive protein, fibrinogen and antithrombin-III are associated with angiographic CAD, history of myocardial infarction and extensive atherosclerotic involvement. Methods: Blood samples were tested for CRP, fibrinogen and AT-III levels from 219 individuals undergoing coronary angiography. Results: CRP was higher in patients with CAD (0.95 +/- 1.31, n = 180, vs. 0.39 +/- 0.61 mg/dl, n = 39, P < 0.0001) and in those with a history of MI (1.07 +/- 1.64, n = 96, vs. 0.65 +/- 0.72 mg/dl, n = 84, P < 0.05) than in control subjects. The patients who developed unstable angina had higher CRPlevels than the patients with stable CAD (2.07 +/- 2.38, n = 7, vs. 0.80 +/- 1.13 mg/dl, n = 173, P < 0.001). Fibrinogen was significantly higher in patients with CAD than in those without CAD (298 +/- 108 vs. 258 +/- 63 mg/dl, P < 0.01). In patients with CAD. mean AT-III value was less than in patients without CAD, but this difference was not statistically significant (P= 0.08). No difference was found in CRP, fibrinogen and ATIII values amongthe patients with single, double or triple vessel disease. Conclusions: CRP is elevated in patients with CAD and a history of MI. Elevated levels of CRP at the time of hospital admission is a predictive valuefor future ischemic events. There is an association between higher levels of fibrinogen and CAD. The association of AT-III levels with CAD needs testing in further studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 09:47:52