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Titolo:
Prevalence of ischemic heart disease in patients with familial Mediterranean fever
Autore:
Langevitz, P; Livneh, A; Neumann, L; Buskila, D; Shemer, J; Amolsky, D; Pras, M;
Indirizzi:
Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel ac Hlth Sci, Beer Sheva, Israel Ben Gurion Univ Negev, Soroka Med Ctr, Rheumat Dis Unit, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel at Dis Unit, Beer Sheva, Israel Ben Gurion Univ Negev, Soroka Med Ctr, Dept Epidemiol, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel t Epidemiol, Beer Sheva, Israel
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 1, volume: 3, anno: 2001,
pagine: 9 - 12
SICI:
1565-1088(200101)3:1<9:POIHDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-A PROTEIN; UNSTABLE ANGINA; PATHOGENESIS; ATHEROSCLEROSIS; INFLAMMATION; COLCHICINE; ATTACKS;
Keywords:
familial Mediterranean fever; ischemic heart disease; inflammation; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Langevitz, P Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 er, Israel
Citazione:
P. Langevitz et al., "Prevalence of ischemic heart disease in patients with familial Mediterranean fever", ISR MED ASS, 3(1), 2001, pp. 9-12

Abstract

Background: Familiar Mediterranean fever is a genetic disorder manifested by recurrent attacks of peritonitis, pleuritis and arthritis, and characterized by clinical, histological and laboratory evidence for localized and systemic inflammation. Colchicine treatment usually prevents the attacks and the associated inflammation. Inflammation may play an important role in theinitiation and progression of atherosclerosis and ischemic heart disease. Objective: To study the effect of inflammation acid its prevention on the occurrence of IHD, using FMF as a model. Methods and Patients: We studied the presence of IHD and its risk factors in 290 FMF patients aged 40 years or more, and in two control groups - 233 spouses of the FMF patients, and 126 patients with inflammatory diseases obtained from other outpatient clinics. FMF patients were also compared with age and gender-matched individuals from the population reference data of the Israel Ministry of Health. Results: The prevalence of IHD in FMF patients was significantly lower than in the group of controls from other outpatient clinics (15.5% vs. 30.2%, P < 0.05) and comparable with their spouses (11.2%) and with the matched general population in Israel (16%). Conclusions: These findings suggest that despite the evidence of recurrentinflammation, colchicine-treated FMF patients are not more predisposed to IHD than the normal population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:41:30