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Titolo:
Penetration of autoantibodies into living cells, 2000
Autore:
Ruiz-Arguelles, A; Alarcon-Segovia, D;
Indirizzi:
Lab Clin Puebla, Dept Immunol, Puebla 72530, Mexico Lab Clin Puebla Puebla Mexico 72530 , Dept Immunol, Puebla 72530, Mexico Natl Inst Med Sci & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico Natl Inst Med Sci & Nutr Salvador Zubiran Mexico City DF Mexico , Mexico
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 2, volume: 3, anno: 2001,
pagine: 121 -
SICI:
1565-1088(200102)3:2<121:POAILC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-DNA ANTIBODIES; MONOCLONAL-ANTIBODIES; IN-VIVO; MEDIATED ENDOCYTOSIS; MONONUCLEAR-CELLS; APOPTOTIC CELLS; INTERNALIZATION; MECHANISMS; THERAPY; CANCER;
Keywords:
autoantibodies; penetration; pathogenesis; physiology; therapeutic applications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ruiz-Arguelles, A Lab Clin Puebla, Dept Immunol, Diaz Ordaz 808, Puebla 72530, Mexico Lab Clin Puebla Diaz Ordaz 808 Puebla Mexico 72530 xico
Citazione:
A. Ruiz-Arguelles e D. Alarcon-Segovia, "Penetration of autoantibodies into living cells, 2000", ISR MED ASS, 3(2), 2001, pp. 121

Abstract

The formerly prevalent concept that intact autoantibodies could not penetrate into viable cells has been defeated by a large amount of experimental findings and clinical observations that indicate otherwise. The penetration of autoantibodies into living cells seems to participate in the pathogenesis of diverse autoimmune diseases, but it may also play a physiological rolein healthy individuals, Although the fine mechanisms of the phenomenon remain to be elucidated, the potential use of penetrating autoantibodies as Vectors to deliver molecules into cells, with diverse therapeutic purposes, has gained growing interest during the last few years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:39:26