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Titolo:
Detection of serum and intrahepatic human hepatocyte growth factor in patients with type C liver diseases
Autore:
Yamagami, H; Moriyama, M; Tanaka, N; Arakawa, Y;
Indirizzi:
Nihon Univ, Sch Med, Dept Internal Med 3, Itabashi Ku, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Med 3, Itabashi Ku, Tokyo 1738610, Japan
Titolo Testata:
INTERVIROLOGY
fascicolo: 1, volume: 44, anno: 2001,
pagine: 36 - 42
SICI:
0300-5526(200101/02)44:1<36:DOSAIH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR-CARCINOMA; EPITHELIAL-CELLS; MESSENGER-RNA; HEPATITIS; EXPRESSION; RATS; HGF; HEPATOBLASTOMA; INCREASE; SYSTEM;
Keywords:
hapatocyte growth factor; chronic hepatitis C; hepatocellular carcinoma; enzyme-linked immunosorbent assay; hepatocyte growth factor expression; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Moriyama, M Nihon Univ, Sch Med, Dept Internal Med 3, Itabashi Ku, 30-1 Oyaguchi Kamimachi, Tokyo 1738610, Japan Nihon Univ 30-1 Oyaguchi Kamimachi Tokyo Japan 1738610 Japan
Citazione:
H. Yamagami et al., "Detection of serum and intrahepatic human hepatocyte growth factor in patients with type C liver diseases", INTERVIROLO, 44(1), 2001, pp. 36-42

Abstract

We determined hepatocyte growth factor (HGF) levels in the serum and liverof patients with hepatitis C and assessed the relationship to histologicalfindings of the liver and hepatitis C virus-related markers in the serum in patients with type C liver diseases. The subjects were 108 patients with chronic hepatitis C (CH), 70 patients with liver cirrhosis C (LC), 38 patients with hepatocellular carcinoma (HCC) and 20 patients with acute hepatitis (AH). As normal controls 20 subjects were studied. The serum HGF levels were measured using an enzyme-linked immunosorbent assay kit. Intrahepatic HGF was investigated by immunoperoxidase staining using monoclonal HGF antibody. The serum HGF level was highest in patients with AH. The serum HGF levels tended to be higher in patients with LC and HCC than those with CH. Further, the serum HGF level was related to the degree of intrahepatic inflammatory cell infiltration and fibrosis, and intrahepatic HGF was noted primarily in the cell membrane of mesenchymal cells in focal necrosis. The degreeof intrahepatic HGF expression tended to be higher in patients with high serum HGF levels. In patients with HCC, however, HGF showed little localization in cancer cells, but was noted in infiltrating mesenchymal cells in both cancerous and noncancerous regions. In conclusion, the measurement of serum HGF levels may be useful for estimating the degree of intrahepatic inflammatory reaction and fibrosis. Although further study is necessary, the high serum level of HGF revealed high carcinogenic states in chronic hepatitisand liver cirrhosis type C. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:46:52