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Titolo:
Gelatin microspheres crosslinked with D,L-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies
Autore:
Vandelli, MA; Rivasi, F; Guerra, P; Forni, F; Arletti, R;
Indirizzi:
Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 to Sci Farmaceut, I-41100 Modena, Italy Univ Modena, Dipartimento Sci Morfol & Medicolegali, I-41100 Modena, ItalyUniv Modena Modena Italy I-41100 l & Medicolegali, I-41100 Modena, Italy Univ Modena, Dipartimento Sci Biomed, Sez Farmacol, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 ed, Sez Farmacol, I-41100 Modena, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 215, anno: 2001,
pagine: 175 - 184
SICI:
0378-5173(20010314)215:1-2<175:GMCWDA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-LINKING; RELEASE;
Keywords:
antihypertensive effect; biocompatibility; clonidine hydrochloride physical properties; D,L-glyceraldehyde; drug release; gelatin microspheres; matrix swelling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Vandelli, MA Univ Modena, Dipartimento Sci Farmaceut, Via G Campi 183, I-41100 Modena, Italy Univ Modena Via G Campi 183 Modena Italy I-41100 dena, Italy
Citazione:
M.A. Vandelli et al., "Gelatin microspheres crosslinked with D,L-glyceraldehyde as a potential drug delivery system: preparation, characterisation, in vitro and in vivo studies", INT J PHARM, 215(1-2), 2001, pp. 175-184

Abstract

To overcome the restriction in using crosslinked gelatin in the pharmaceutical field, D,L-glyceraldehyde (GAL), a non-toxic crosslinking agent, was proposed. Gelatin microspheres crosslinked with different concentrations of GAL (0.5, 1 or 2%, w/v) and for different time periods (1 or 24 h) were prepared. The effect of the preparation variables was evaluated analysing the extent of crosslinking, the morphological aspect, the particle size and theswelling behaviour. To evaluate the pharmaceutical properties, an antihypertensive drug, clonidine hydrochloride, was chosen as drug model and loadedinto the microspheres. Either the increase of the crosslinker concentration or of the crosslinking time period decreased both the swelling and the invitro drug release processes of the microspheres. After the subcutaneous injection, the loaded microspheres crosslinked with the lowest GAL concentration (0.5%. w/v) or for the shortest time period (1 h) showed a reduction of systolic blood pressure (SBP) similar to that recorded with a clonidine hydrochloride solution having the same drug concentration. Instead, the microspheres crosslinked for 24 h with concentrations of GAL higher than 0.5% (w/v) produced a more gradual and sustained SEP reduction and the antihypertensive effect was maintained until 52-72 h. The biocompatibility studies showed that the microspheres crosslinked with GAL are well tolerated in vivo. These results suggest the potential application of gelatin microspheres crosslinked with GAL as a suitable drug delivery system for the subcutaneous administration. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:46:11