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Titolo:
Significance of integrin alpha 2/beta 1 in peritoneal dissemination of a human gastric cancer xenograft model
Autore:
Kawamura, T; Endo, Y; Yonemura, Y; Nojima, N; Fujita, H; Fujimura, T; Obata, T; Yamaguchi, T; Sasaki, T;
Indirizzi:
Kanazawa Univ, Canc Res Inst, Dept Expt Therapeut, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan Kanazawa Univ, Sch Med, Dept Surg 2, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan Kanazawa Univ, Dept Electron Microscopy, Kanazawa, Ishikawa 9200934, JapanKanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 4, volume: 18, anno: 2001,
pagine: 809 - 815
SICI:
1019-6439(200104)18:4<809:SOIA21>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-5-BETA-1-FIBRONECTIN RECEPTOR; ALPHA-2-BETA-1 INTEGRIN; RHABDOMYOSARCOMA CELLS; ADHESION MOLECULES; CARCINOMA-CELLS; I COLLAGEN; METASTASIS; EXPRESSION; BINDING; INVASION;
Keywords:
integrin alpha 2; integrin beta 1; peritoneal dissemination; gastric cancer; MKN-45-P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, T Kanazawa Univ, Canc Res Inst, Dept Expt Therapeut, 13-1 Takara Machi, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9200934
Citazione:
T. Kawamura et al., "Significance of integrin alpha 2/beta 1 in peritoneal dissemination of a human gastric cancer xenograft model", INT J ONCOL, 18(4), 2001, pp. 809-815

Abstract

In the present study, the role of integrin alpha2/beta1 in peritoneal dissemination of gastric cancer was investigated using an in vivo xenograft model for the highly metastatic MKN-45-P gastric cancer cells. Metastatic ability of MKN-45-P cells was significantly associated with the simultaneous expression of integrin alpha2 and alpha3 subunits. In an in vitro adhesion assay, neutralizing antibody for integrin alpha2 or beta1 subunit: inhibited the adhesion of MKN-45-P cells to collagen type I and type IV: Moreover, the injection of anti-beta1 monoclonal antibody reduced the number of cancer cells on the peritoneum in nude mice that had been inoculated with MKN-45-Pcells. These results suggest that integrin alpha2/beta1 represents a candidate target molecule available for the prevention of gastric cancer peritoneal dissemination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:20:39