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Titolo:
Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro
Autore:
Utkan, T; Yildirim, MK; Yildirim, S; Sarioglu, Y;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 Pharmacol, TR-58140 Sivas, Turkey
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 1, volume: 13, anno: 2001,
pagine: 24 - 30
SICI:
0955-9930(200102)13:1<24:EOTSPI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; INTESTINAL POLYPEPTIDE VIP; SMOOTH-MUSCLE TONE; CORPUS CAVERNOSUM; NITRIC-OXIDE; IN-VITRO; ERECTILE DYSFUNCTION; PENILE ERECTION; GMP; AMP;
Keywords:
penile erection; phosphodiesterase inhibitors; diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 , TR-41900 Kocaeli, Turkey
Citazione:
T. Utkan et al., "Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro", INT J IMPOT, 13(1), 2001, pp. 24-30

Abstract

An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction, Relaxant effect of specific PDE inhibitors were measured in strips of corpuscavernosum smooth muscle taken from control and diabetic groups. Diabetes mellitus was induced in New Zealand white rabbits using alloxan, Penises excised from diabetic rabbits 8 weeks after the induction of diabetes mellitus, In the organ bath strips from control and diabetic rabbit corpus cavernosum were precontracted and increasing doses of several PDE inhibitors were added. In the precontracted rabbit cavernous tissue, sulmazole and zaprinast specific PDE V inhibitors were equally potent and efficacious in vitro but amrinone, a specific PDE III inhibitor, exhibits low relaxant effects. All PDE inhibitors tested showed a similar relaxation effect on corpus cavernosum smooth muscle from control and 8-week diabetic rabbits, The present study provides the possibility of using selective PDE III and V inhibitors inthe treatment of diabetic impotence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:51:20