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Titolo:
Previous pulmonary diseases and risk of lung cancer in Gansu Province, China
Autore:
Brenner, AV; Wang, ZY; Kleinerman, RA; Wang, LD; Zhang, SZ; Metayer, C; Chen, K; Lei, SW; Cui, HX; Lubin, JH;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Radiat Epidemiol Branch, Bethesda, MD 20892 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
fascicolo: 1, volume: 30, anno: 2001,
pagine: 118 - 124
SICI:
0300-5771(200102)30:1<118:PPDARO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSMOKING WOMEN; FAMILY HISTORY; TUBERCULOSIS PATIENTS; RESPIRATORY-DISEASE; MORTALITY; SMOKING; COHORT; EXPOSURE; ASTHMA; MINERS;
Keywords:
case-control studies; lung neoplasms; tuberculosis; pulmonary; bronchitis; pulmonary emphysema; asthma; pneumonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Brenner, AV NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, 6120Execut Blvd,MSC 7362, Bethesda, MD 20892 USA NCI 6120 Execut Blvd,MSC 7362Bethesda MD USA 20892 20892 USA
Citazione:
A.V. Brenner et al., "Previous pulmonary diseases and risk of lung cancer in Gansu Province, China", INT J EPID, 30(1), 2001, pp. 118-124

Abstract

Backgrounds Although active smoking is well established as the main cause of lung cancer, there is accumulating evidence that history of prior lung diseases may be an independent risk factor for lung cancer. Methods A population-based case-control study in Gansu Province, China identified 886 lung cancer cases (656 male, 230 female) diagnosed between January 1994 and April 1998. A standardized interview collected information on a variety of potential risk factors including a history of physician-diagnosed non-malignant lung diseases (pulmonary tuberculosis, chronic bronchitis/emphysema, asthma, pneumonia), age and year in which each condition was first diagnosed, and any therapy or hospitalization received. Results Pulmonary tuberculosis (odds ratio [OR] = 2.1, 95% CI:1.4-3.1) andchronic bronchitis/emphysema (OR = 1.4 95% CI : 1.1-1.8) were associated with increased risk of lung cancer, after adjustment for active smoking and socioeconomic status. The OR for asthma (OR = 1.4, 95% CI : 0.9-2.1) and pneumonia (OR = 1.5, 95% CI: 1.0-2.3) were also elevated. The risk of lung cancer remained significant for pulmonary tuberculosis and chronic bronchitis/emphysema when analysis was limited to the pathologically confirmed cases and self-responders. Conclusions This study provides additional evidence that previous pulmonary tuberculosis and chronic bronchitis/emphysema are causally related to lung cancer, although the precise mechanism is still unclear. The results for asthma and pneumonia, while suggestive of a positive association, did not reach the traditional level of statistical significance and should be interpreted with caution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:10:37