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Titolo:
Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer
Autore:
De Angelis, PM; Stokke, T; Beigi, M; Mjaland, O; Clausen, OPF;
Indirizzi:
Norwegian Natl Hosp, Inst Pathol, N-0027 Oslo, Norway Norwegian Natl HospOslo Norway N-0027 Inst Pathol, N-0027 Oslo, Norway
Titolo Testata:
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
fascicolo: 1, volume: 16, anno: 2001,
pagine: 38 - 45
SICI:
0179-1958(200102)16:1<38:PSORCA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENES; ALLELIC LOSS; MUTATIONAL ANALYSIS; COLON-CARCINOMA; GAINS; P53; SURVIVAL; DPC4; 18Q; ADENOCARCINOMAS;
Keywords:
colorectal tumors; comparative genomic hybridization; chromosomal gains/losses; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: De Angelis, PM Norwegian Natl Hosp, Inst Pathol, N-0027 Oslo, Norway Norwegian Natl Hosp Oslo Norway N-0027 -0027 Oslo, Norway
Citazione:
P.M. De Angelis et al., "Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer", INT J COL R, 16(1), 2001, pp. 38-45

Abstract

Colorectal carcinomas are characterized by frequent recurrent gains and losses of chromosomal material, especially gains of chromosome arms 20q and 13q, and losses of chromosome arms 18q and 4q. These may be important in thedevelopment and progression of colorectal carcinomas. Chromosomal aberrations detected by comparative genomic hybridization in 67 sporadic colorectalcarcinomas were examined for their possible associations with patient survival. Dukes' stage, tumor DNA ploidy status, and TP53 genotype/phenotype were also examined for the same. Patients with losses of chromosomal arms 1p,4q, 8p, 14q, or 18q or gain of chromosomal arm 20q had significantly shorter survival times than those without these aberrations (univariate relativerisk 3.45, 2.71, 3.32, 3.26, 3.32, 3.91, respectively), as did patients with more than six chromosomal aberrations per tumor than those with fewer than six aberrations (univariate relative risk 3.26, P=0.013). DNA aneuploidyand Dukes' stage C+D resulted in poor patient survival (univariate relative risk 3.58, 3.39, respectively). Dukes' stage C+D, 1p loss and 8p loss emerged as the only independent prognostic parameters (relative risk 3.22, 2.53, 2.45, respectively) when entered into multivariate survival analysis together with other significant parameters from univariate survival analysis. Loss of chromosome arm 1p, 4q, 8p, 14q, or 18q or gain of chromosome arm 20q thus results in shortened survival times in colorectal cancer patients. 1p loss and 8p loss were shown to be independent predictors of poor prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:30:14