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Titolo:
Age-dependent variation in contractility of adult cardiac myocytes
Autore:
Nair, RR; Nair, P;
Indirizzi:
Sree Chitra Tirunal Inst Med Sci & Technol, Div Cellular & Mol Cardiol, Thiruvananthapuram 695011, Kerala, India Sree Chitra Tirunal Inst Med Sci & Technol Thiruvananthapuram Kerala India 695011
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 2, volume: 33, anno: 2001,
pagine: 119 - 125
SICI:
1357-2725(200102)33:2<119:AVICOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATPASE ACTIVITY; RAT; MUSCLE; MYOCARDIUM; RESPONSES; CURRENTS; CHANNELS; CALCIUM; HEARTS; CELLS;
Keywords:
adult age; cardiac myocytes; contractility; mechanical response; calcium channel antagonists;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Nair, RR Sree Chitra Tirunal Inst Med Sci & Technol, Div Cellular & Mol Cardiol, Thiruvananthapuram 695011, Kerala, India Sree Chitra Tirunal Inst Med Sci & Technol Thiruvananthapuram Kerala India 695011
Citazione:
R.R. Nair e P. Nair, "Age-dependent variation in contractility of adult cardiac myocytes", INT J BIO C, 33(2), 2001, pp. 119-125

Abstract

This study was designed to examine the influence of the age of adults on the contractile characteristics of the myocardium and to ascertain whether the age dependent variation is related to variation in sarcolemmal calcium channels. Cardiomyocytes were isolated from 2, 6 and 12-month-old, male Sprague-Dawley rats and the extent and velocity of contraction were recorded asa function of change in cell length. Age dependent increase in cell lengthand sarcomere length was significant (P < 0.05). Extent of contraction increased with age and the velocities of contraction and relaxation normalizedto total contraction decreased with age (P < 0.05). Sensitivity to the L-type channel antagonist (verapamil, 1 muM) and the T-type channel antagonist(nickel chloride, 40 muM) was significant in 6 and 12-month-old animals. This differential response to calcium channel antagonists suggests that the age-dependent variation in contractility may be mediated by the variation in the distribution/function of sarcolemmal calcium channels. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:24:20