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Titolo:
Observations on amphotericin B treatment of kala-azar given in a rural setup in Bihar, India
Autore:
Thakur, CP; Ahmed, S;
Indirizzi:
Balaji Uttahan Sansthan, Patna 800001, Bihar, India Balaji Uttahan Sansthan Patna Bihar India 800001 tna 800001, Bihar, India Imarat Saria, Patna, Bihar, India Imarat Saria Patna Bihar IndiaImarat Saria, Patna, Bihar, India
Titolo Testata:
INDIAN JOURNAL OF MEDICAL RESEARCH
, volume: 113, anno: 2001,
pagine: 14 - 18
SICI:
0971-5916(200101)113:<14:OOABTO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISCERAL LEISHMANIASIS; SODIUM STIBOGLUCONATE; NORTH BIHAR; LINE DRUG; DEOXYCHOLATE; PENTAMIDINE; REGIMENS; INVITRO;
Keywords:
amphotericin B; kala-azar; rural; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Thakur, CP Balaji Uttahan Sansthan, Fraser Rd, Patna 800001, Bihar, India Balaji Uttahan Sansthan Fraser Rd Patna Bihar India 800001 ndia
Citazione:
C.P. Thakur e S. Ahmed, "Observations on amphotericin B treatment of kala-azar given in a rural setup in Bihar, India", I J MED RES, 113, 2001, pp. 14-18

Abstract

Background & objectives : In a kala-azar endemic area in rural Bihar with a large number of patients unresponsive to sodium antimony gluconate and pentamidine, treatment with amphotericin B was tried in a rural set-up with the objective to cure these patients, and to assess whether such a centre could he run successfully in a rural set-up. Methods : After thorough clinical examination and biochemical investigations, parasitologically confirmed patients who had haemoglobin above 5 g/dl, electrolyte imbalance if any, corrected, and ECG changes suggestive of myocardial damage stabilised after 10 days of bed rest were treated. Amphotericin B deoxycholate was infused at a dose of 1 mg/kg body weight daily for 20days. The adverse events were closely monitored. Results : All 7 (100%) untreated patients of kala-azar, 258 (97%) of the 266 antimony and pentamidine resistant patients, and 31 (86%,) of the 36 patients who had relapsed after a low dose regimen of amphotericin B, were cured with 20 infusions of amphotericin B. Eight (3%) patients of the antimonyand pentamidine resistant group anti 5 (14%) patients who had relapsed after low dose amphotericin B regimen required 25 infusions of amphotericin B to achieve parasitological cure. Interpretation & conclusions : With some precautions and proper management, all patients of kala-azar could be cured with amphotericin B in a rural set-up. A significant (P<0.05) percentage of patients of group C relapsing after a low dose amphotericin B regime requiring 25 infusions for cure suggests that an adequate dose regime of amphotericin B should be given during the first course of treatment to prevent emergence of drug resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:09:30