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Titolo:
EARLY POSTNATAL TREATMENT WITH TRANSFORMING-GROWTH-FACTOR-ALPHA DOES NOT ALTER NONREPRODUCTIVE BEHAVIOR
Autore:
HILAKIVICLARKE L; CHO E; RAYGADA M;
Indirizzi:
GEORGETOWN UNIV,VINCENT T LOMBARDI CANC RES CTR,RES BLDG,ROOM W405,3970 RESERVOIR RD NW WASHINGTON DC 20007 GEORGETOWN UNIV,DEPT PSYCHIAT WASHINGTON DC 20007
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 62, anno: 1997,
pagine: 207 - 211
SICI:
0031-9384(1997)62:1<207:EPTWTD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; TGF-ALPHA; STEROID-HORMONES; MICE; ESTROGEN; DIETHYLSTILBESTROL; MOUSE; EXPRESSION; ALCOHOL;
Keywords:
TRANSFORMING GROWTH FACTOR ALPHA; ESTRADIOL; NONREPRODUCTIVE BEHAVIOR; NEONATAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L. Hilakiviclarke et al., "EARLY POSTNATAL TREATMENT WITH TRANSFORMING-GROWTH-FACTOR-ALPHA DOES NOT ALTER NONREPRODUCTIVE BEHAVIOR", Physiology & behavior, 62(1), 1997, pp. 207-211

Abstract

Estrogen acting during the critical developmental period has been postulated to defeminize and possibly masculinize male sexual behavior. Transforming growth factor alpha (TGF alpha) also may be involved, because this growth factor, at least partly, mediates the mitotic effects of estrogen on target tissues. Male transgenic mice overexpressing TGFalpha have elevated serum estradiol (E2) levels and they exhibit feminization of many nonreproductive actions, suggesting that either TGF alpha and/or E2, or both, participate in the control of some nonreproductive behavior. Male and female CD-1 mice were treated with 4 mu g of recombinant human TGF alpha or 2-4 mu g E2 during the first 3 days of life. Although early TGF alpha treatment accelerates physical development and influences the growth of the uterus and mammary gland, it failed to have any effect on behavior, either in male or female mice. Early E2 treatment significantly lengthened immobility time in the swim test and reduced voluntary alcohol intake among the male mice. No changes in locomotor activity or aggressive behavior were noted. The expression of TGF alpha mRNA in the brainstem of adult male mice was not altered following neonatal TGF alpha or E2 treatment. However, neonatal exposure to TGF alpha caused a moderate elevation in TGF alpha mRNA expression in the female brainstem. Our results indicate that in male, butnot in female mice, an excess of E2 during early life affects some nonreproductive behavior. Furthermore, early treatment with recombinant human TGF alpha does not alter nonreproductive behavior in mice. (C) 1997 Elsevier Science Inc.

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Documento generato il 21/09/20 alle ore 11:53:08