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Titolo:
OPIOID-RECEPTOR SUBTYPE AGONIST-INDUCED ENHANCEMENTS OF SUCROSE INTAKE ARE DEPENDENT UPON SUCROSE CONCENTRATION
Autore:
RUEGG H; YU WZ; BODNAR RJ;
Indirizzi:
CUNY QUEENS COLL,NEUROPSYCHOL DOCTORAL SUBPROGRAM,65-30 KISSENA BLVD FLUSHING NY 11367 CUNY QUEENS COLL,NEUROPSYCHOL DOCTORAL SUBPROGRAM FLUSHING NY 11367
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 62, anno: 1997,
pagine: 121 - 128
SICI:
0031-9384(1997)62:1<121:OSAEOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; NALOXONE BENZOYLHYDRAZONE; BINDING-SITES; FOOD-INTAKE; DIFFERENTIAL ANTAGONISM; DELTA-ANTINOCICEPTION; PUTATIVE REINFORCERS; LOCOMOTOR ACTIVITIES; SACCHARIN INTAKE; WATER-INTAKE;
Keywords:
DELTA(1) RECEPTOR; DELTA(2) RECEPTOR; KAPPA(1) RECEPTOR; KAPPA(3) RECEPTOR; MU RECEPTOR; SUCROSE INTAKE; OPIOIDS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
H. Ruegg et al., "OPIOID-RECEPTOR SUBTYPE AGONIST-INDUCED ENHANCEMENTS OF SUCROSE INTAKE ARE DEPENDENT UPON SUCROSE CONCENTRATION", Physiology & behavior, 62(1), 1997, pp. 121-128

Abstract

Selective mu ([D-Ala(2), N-Me-Phe(4), Gly-ol(5)]-enkephalin (DAMGO)),delta, ([D-Pen(2), D-Pen(5)]-enkephalin (DPDPE)), delta(2) ([D-Ala(2), Glu(4)]-Deltorphin (Delt II)), kappa, (U50488H) and kappa, (naloxonebenzoylhydrazone (NalBzOH) opioid agonists each stimulate food intakein rats. Whereas studies with selective opioid antagonists implicate mu and kappa(1) receptors in the mediation of sucrose intake, studies with selective opioid agonists implicate mu and delta receptors in themediation of saccharin intake. The present study determined if specific delta(1), delta(2), kappa(1), kappa(3) and mu opioid-receptor subtype agonists produced similar alter-ations in sucrose intake as a function of sucrose concentration (0.5%, 2.5%, 10%) across a 1-h time-course. Each of these agonists significantly increased sucrose intake with variations in pattern, magnitude, and consistency as a function of sucrose concentration. Whereas the mu opioid agonist, DAMGO, and the delta, opioid agonist, DPDPE, each enhanced sucrose intake at higher (2.5%, 10%), but not lower (0.5%), concentrations, the delta(2) opioid agonist, DeIt II, increased sucrose intake at lower (0.5%, 2.5%, 2.5%), but not higher (10%), concentrations. Kappa opioid agonists produced less consistent effects. The kappa(1) opioid agonist, U50488H, increased sucrose intake at high (10%) concentrations and decreased sucrose intake at low (0.5%) concentrations, and the kappa(3) opioid agonist, NalBzOH, inconsistently increased sucrose intake at the 0.5% (20 mu g) and10% (1 mu g) concentrations. Thus, these data further implicate mu, delta(1), and delta(2) opioid mediation of palatable intake, particularly of its orosensory characteristics. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:55:16