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Titolo:
Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition
Autore:
Brands, MW; Hailman, AE; Fitzgerald, SM;
Indirizzi:
Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Dept Physiol, Augusta, GA 30912 USA Univ Mississippi, Med Ctr, University, MS 38677 USA Univ Mississippi University MS USA 38677 ed Ctr, University, MS 38677 USA
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 37, anno: 2001,
parte:, 2 supplemento:, S
pagine: 733 - 738
SICI:
0194-911X(200102)37:2<733:LGIIAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HYPERINSULINEMIA; INSULIN-RESISTANCE; BLOOD-PRESSURE; INDUCED HYPERTENSION; RATS; NIMESULIDE; METABOLISM; NSAIDS;
Keywords:
insulin; hypertension; prostaglandins; COX-2; renin-angiotensin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Brands, MW Med Coll Georgia, Dept Physiol, 1120 15th St, Augusta, GA 30912USA Med Coll Georgia 1120 15th St Augusta GA USA 30912 GA 30912 USA
Citazione:
M.W. Brands et al., "Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition", HYPERTENSIO, 37(2), 2001, pp. 733-738

Abstract

A series of studies has shown that long-term infusion of insulin and glucose does not increase mean arterial pressure (MAP) in dogs, but we have shown that the same infusion protocol or infusion of glucose alone increases arterial pressure in rats, This study tested the hypothesis that infusing glucose alone in dogs, with all insulin derived from endogenous secretion, would increase arterial pressure. Because fructose feeding in dogs also has been shown not to cause hypertension and because we have shown that prostaglandin production increases during insulin and glucose infusion, this study also tested whether prostaglandins prevent the presser response in dogs. Dogs were instrumented and assigned in random crossover design to long-term cyclooxygenase-2 (COX-2) inhibition. After baseline measurements, glucose wasinfused in all dogs for 6 days (approximate to 500 g/d IV). Plasma insulinincreased 3- to 4-fold and blood glucose increased significantly in both groups. The MAP (measured 24 h/d) response in control dogs was variable but on average tended to increase, although not significantly. In the dogs withCOX-2 inhibition, however, MAP increased significantly to a peak of 9+/-2 mm Hg and an average of 6+/-1 mm Hg above control. There was significant sodium and volume retention during glucose infusion and a significant increase in glomerular filtration rate, but there were no between-group differences. Plasma renin activity increased only in the control group. This is the first study to report a long-term presser response with glucose infusion andhyperinsulinemia in dogs, and it suggests that the inability to detect this relationship previously was due to prostaglandins.

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Documento generato il 04/07/20 alle ore 17:47:01