Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Degeneration of capsaicin-sensitive sensory nerves leads to increased saltsensitivity through enhancement of sympathoexcitatory response
Autore:
Wang, DH; Wu, W; Lookingland, KJ;
Indirizzi:
Michigan State Univ, Dept Med & Pharmacol & Toxicol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 xicol, E Lansing, MI 48824 USA
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 37, anno: 2001,
parte:, 2 supplemento:, S
pagine: 440 - 443
SICI:
0194-911X(200102)37:2<440:DOCSNL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; RAT; HYPERTENSION; NEURONS; DENERVATION; 6-HYDROXYDOPAMINE; NUCLEUS; MODEL;
Keywords:
denervation; sympathectomy; hypertension, sodium-dependent; sodium, dietary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, DH Michigan State Univ, Coll Human Med, Dept Med, Clin Ctr B316, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Lansing, MI 48824 USA
Citazione:
D.H. Wang et al., "Degeneration of capsaicin-sensitive sensory nerves leads to increased saltsensitivity through enhancement of sympathoexcitatory response", HYPERTENSIO, 37(2), 2001, pp. 440-443

Abstract

We have previously shown that neonatal degeneration of capsaicin-sensitivesensory nerves renders a rat responsive to a salt load with an increase inblood pressure and a decrease in natriuretic response. To test the hypothesis that the enhanced svmpathoexcitatory response to a high salt intake contributes to the development of hypertension in this model, newborn Wistar rats were given 50 mg/kg capsaicin and/or 80 mg/kg guanethidine subcutaneously. Control rats were treated with vehicle. After the weaning period, male rats were grouped as the following and given a high sodium diet (4%) for 2 weeks: capsaicin and guanethidine coadministration (CAP-GUA), capsaicin only (CAP), guanethidine only (CUA), and vehicle control (CON). Norepinephrineconcentrations in the atrium were significantly lower in CAP-GUA and GUA than in CON rats (P<0.05). Twenty-four-hour urine and sodium excretions weresignificantly lower in CAP than in CAP-GUA, GUA, and CON rats (P<0.05). Mean arterial pressure (mm Hg) was significantly higher in CAP (180+/-10) than in CAP-GUA (106+/-1), GUA (133+/-5), and CON (122+/-3) rats (P<0.05). Thus, sympathectomy restores the natriuretic response to a high salt intake and prevents the development of salt-sensitive hypertension induced by sensory denervation, These data indicate that sensory nerves counterbalance the prohypertensive effect of the sympathetic nerves to maintain blood pressure within normal range during salt loading.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:17:25